Analysis Tools
endocrine/exocrine glands
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• 16 week old adult virgin mice show a reduction in mammary gland complexity
• mammary glands exhibit reduced mitosis
• the non-neoplastic mammary gland tissues show a variety of abnormalities including persistent terminal end buds, secretory hyperplasia, and atypical ductal hyperplasia
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• abnormal age-related involution in virgin mice, with all mice at 8 months of age showing residual brown adipose tissue in the mammary glands and terminal end buds that persist in 66.7% of these mice
• however, dams are able to nurse litters and glands undergo post-lactational involution
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• hypoplastic ductal epithelium with reduced ductal thickness in 16 week old virgin mice
• ductal epithelial cells are flat instead of tall columnar
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• pre-pubertal (5 week) and pubertal (8 week) mice exhibit reduced numbers of terminal end buds and of bifurcated terminal end buds
• persistent terminal end buds are seen in the non-neoplastic mammary gland tissues
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• atypical ductal hyperplasia is seen in the non-neoplastic mammary gland tissues
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• 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months
• mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas
• tumors are highly invasive into the surrounding mammary tissues and skeletal muscle
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integument
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• mammary glands exhibit reduced mitosis
• 16 week old adult virgin mice show a reduction in mammary gland complexity
• the non-neoplastic mammary gland tissues show a variety of abnormalities including persistent terminal end buds, secretory hyperplasia, and atypical ductal hyperplasia
|
|
|
• abnormal age-related involution in virgin mice, with all mice at 8 months of age showing residual brown adipose tissue in the mammary glands and terminal end buds that persist in 66.7% of these mice
• however, dams are able to nurse litters and glands undergo post-lactational involution
|
|
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• hypoplastic ductal epithelium with reduced ductal thickness in 16 week old virgin mice
• ductal epithelial cells are flat instead of tall columnar
|
|
|
• pre-pubertal (5 week) and pubertal (8 week) mice exhibit reduced numbers of terminal end buds and of bifurcated terminal end buds
• persistent terminal end buds are seen in the non-neoplastic mammary gland tissues
|
|
|
• atypical ductal hyperplasia is seen in the non-neoplastic mammary gland tissues
|
|
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• 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months
• mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas
• tumors are highly invasive into the surrounding mammary tissues and skeletal muscle
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neoplasm
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• 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months
• mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas
• tumors are highly invasive into the surrounding mammary tissues and skeletal muscle
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• distant metastasis develop in 46.2% of tumor-bearing mice, mainly to the lungs and in once case the soft tissues of the neck
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast metaplastic carcinoma | DOID:4680 | J:241259 | ||
