Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tgfb1i1tm1.2Cet targeted mutation 1.2. Christopher E Turner MGI:6093696 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mammary gland ducts have reduced penetration into the fat pad in 6 week old mice, however by 10 weeks of age, this difference is no longer seen
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• mammary gland ducts have reduced penetration into the fat pad in 6 week old mice, however by 10 weeks of age, this difference is no longer seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• onset of palpable mammary tumor formation is slightly delayed and growth of the primary tumor is reduced compared to control heterozygous Tgfb1i1tm1.1Cet Tg(MMTV-PyVT)634Mul mice
• tumor stroma contains fewer cancer-associated fibroblasts and reduced extracellular matrix deposition
• isolated cancer-associated fibroblasts are defective in stress fiber organization and exhibit reduced contractility
• more than 2-fold reduction in the number of proliferating cells in mammary tumors
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• mammary tumors exhibit fewer lung metastases than controls
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• onset of palpable mammary tumor formation is slightly delayed and growth of the primary tumor is reduced compared to control heterozygous Tgfb1i1tm1.1Cet Tg(MMTV-PyVT)634Mul mice
• tumor stroma contains fewer cancer-associated fibroblasts and reduced extracellular matrix deposition
• isolated cancer-associated fibroblasts are defective in stress fiber organization and exhibit reduced contractility
• more than 2-fold reduction in the number of proliferating cells in mammary tumors
|
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|
• onset of palpable mammary tumor formation is slightly delayed and growth of the primary tumor is reduced compared to control heterozygous Tgfb1i1tm1.1Cet Tg(MMTV-PyVT)634Mul mice
• tumor stroma contains fewer cancer-associated fibroblasts and reduced extracellular matrix deposition
• isolated cancer-associated fibroblasts are defective in stress fiber organization and exhibit reduced contractility
• more than 2-fold reduction in the number of proliferating cells in mammary tumors
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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