Phenotypes associated with this allele

• Allele Symbol: Rfwd3^tm1.1Dtch
• Allele Name: targeted mutation 1.1, Detlev Schindler
• Allele ID: MGI:6093702
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rfwd3^tm1.1Dtch/Rfwd3^tm1.1Dtch	involves: C57BL/6	MGI:6093705

Genotype
MGI:6093705

hm1

• Allelic Composition: Rfwd3^tm1.1Dtch/Rfwd3^tm1.1Dtch
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:248005 )

• for unknown reasons

reproductive system

oligozoospermia ( J:248005 )

♂

impaired ovarian folliculogenesis ( J:248005 )

♀ • no follicular differentiation or development is detected

small ovary ( J:248005 )

♀

ovary atrophy ( J:248005 )

♀

testicular atrophy ( J:248005 )

♂

reduced female fertility ( J:248005 )

♀ • possibly infertility

reduced male fertility ( J:248005 )

♂ • possibly infertility

cellular

oligozoospermia ( J:248005 )

♂

increased cellular sensitivity to DNA damaging agents ( J:248005 )

• mouse embryonic fibroblasts treated with mitomycin C exhibit increased G2 phase accumulation, chromosomal breakage and cell death compared with wild-type cells

endocrine/exocrine glands

impaired ovarian folliculogenesis ( J:248005 )

♀ • no follicular differentiation or development is detected

small ovary ( J:248005 )

♀

ovary atrophy ( J:248005 )

♀

testicular atrophy ( J:248005 )

♂