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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rorctm1.1Zsun
targeted mutation 1.1, Zuoming Sun
MGI:6095621
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rorctm1.1Zsun/Rorctm1.1Zsun B6(129S4)-Rorctm1.1Zsun MGI:6115817


Genotype
MGI:6115817
hm1
Allelic
Composition		 Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic
Background		 B6(129S4)-Rorctm1.1Zsun
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorctm1.1Zsun mutation (1 available); any Rorc mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T-helper 17 cell differentiation ( J:248565 )
• T cells fail to differentiate in IL17-producing cells, however T cells can differentiate into TH1, TH2 and regulatory T cells
absent Peyer's patches ( J:248565 )
• mice fail to develop Peyer's patches
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:248565 )
• EAE development is attenuated in females immunized with EAE-inducing MOG epitope

hematopoietic system
abnormal T-helper 17 cell differentiation ( J:248565 )
• T cells fail to differentiate in IL17-producing cells, however T cells can differentiate into TH1, TH2 and regulatory T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory