About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-Ab1g7-em1Dvs
endonuclease-mediated mutation 1, Jackson
MGI:6101479
Summary 1 genotype


Genotype
MGI:6119570
cx1
Allelic
Composition		 H2-Ab1g7-em1Dvs/H2-Ab1g7-em1Dvs
H2-D1b-em5Dvs/H2-D1b-em5Dvs
H2-K1d-em1Dvs/H2-K1d-em1Dvs
Genetic
Background		 NOD/ShiLtDvs-H2-K1d-em1Dvs H2-Ab1g7-em1Dvs H2-D1em5Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1g7-em1Dvs mutation (1 available); any H2-Ab1 mutation (83 available)
H2-D1b-em5Dvs mutation (4 available); any H2-D1 mutation (47 available)
H2-K1d-em1Dvs mutation (4 available); any H2-K1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell subpopulation ratio ( J:257229 )
• in addition to the altered CD4+ and CD8+ numbers, there is a slight increase in the number of CD4/CD8 double negative and NKT cells relative to H2 class I null/class II intact mice
decreased alpha-beta T cell number ( J:257229 )
• only approximately 12% of splenocytes are Thy1.2+, and of these only 60% are alpha/beta T cells with an increase in percentage of gamma/delta T cells
• there are fewer splenic CD8+ T cells than in NOD controls but more than in histocompatibility class I null/class II intact mice
decreased CD4-positive, alpha-beta T cell number ( J:257229 )
• drastically reduced CD4+ splenocyte number

immune system
abnormal T cell subpopulation ratio ( J:257229 )
• in addition to the altered CD4+ and CD8+ numbers, there is a slight increase in the number of CD4/CD8 double negative and NKT cells relative to H2 class I null/class II intact mice
decreased alpha-beta T cell number ( J:257229 )
• only approximately 12% of splenocytes are Thy1.2+, and of these only 60% are alpha/beta T cells with an increase in percentage of gamma/delta T cells
• there are fewer splenic CD8+ T cells than in NOD controls but more than in histocompatibility class I null/class II intact mice
decreased CD4-positive, alpha-beta T cell number ( J:257229 )
• drastically reduced CD4+ splenocyte number
decreased susceptibility to autoimmune diabetes ( J:257229 )
• between 9 and 12 weeks of age no insulitis is found




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory