Phenotypes associated with this allele

• Allele Symbol: Usp6nl^tm1.1Ppdf
• Allele Name: targeted mutation 1.1, Pier Di Fiore
• Allele ID: MGI:6102918
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp6nl^tm1.1Ppdf/Usp6nl^tm1.1Ppdf	involves: C57BL/6	MGI:6362730

Genotype
MGI:6362730

hm1

• Allelic Composition: Usp6nl^tm1.1Ppdf/Usp6nl^tm1.1Ppdf
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased fibroblast cell migration ( J:247704 )

• total distance and cell velocity are increased in primary embryonic fibroblasts in Dunn chamber assays in the absence of any diffusible gradient, while directionality is not altered, indicating enhanced cell migration

• primary embryonic fibroblasts plated on fibronectin show improved forward migration

• however, migration on vitronectin is not altered

increased fibroblast chemotaxis ( J:247704 )

• chemotactic migration of primary embryonic fibroblasts to a PDGF gradient is increased, with an increase in the distance and velocity without affecting the persistency of random cell migration

reproductive system

reproductive system phenotype ( J:247704 )

N • mice are viable and fertile and do not display gross abnormalities