Analysis Tools
mortality/aging
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• about 1/3 of tamoxifen-injected mice die within 28 days, although not all of these mice are edematous or ill
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cardiovascular system
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• interstitial space between myocytes is increased in hearts of tamoxifen treated mice, although only a minimal increase in interstitial fibrosis is seen
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• mice exhibit enlarged hearts after 28 days of tamoxifen treatment
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• mice exhibit a 1.89-fold increase in heart weight/tibial length ratio after 28 days of tamoxifen injection
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• mice exhibit ventricular dilatation after 28 days of tamoxifen treatment
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• in tamoxifen treated mice
• however, myocyte hypertrophy is not seen
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• both maximum and minimum dP/dt values are altered after 7 days of tamoxifen treatment, indicating a contractile defect affecting both contraction and relaxation phase of the heart beat
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• both maximum and minimum dP/dt values are altered after 7 days of tamoxifen treatment, indicating a contractile defect affecting both contraction and relaxation phase of the heart beat
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• left ventricle end diastolic pressure is elevated 21-fold, and left ventricle end systolic presure and ejection fractions are depressed in tamoxifen treated mice
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• heart rate is depressed in tamoxifen treated mice
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• tamoxifen-treated myocytes exhibit a decrease in L-type calcium current density
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• mice progress into overt heart failure with continued tamoxifen treatment
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growth/size/body
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• mice exhibit enlarged hearts after 28 days of tamoxifen treatment
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• mice exhibit a 1.89-fold increase in heart weight/tibial length ratio after 28 days of tamoxifen injection
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weight loss
(
J:104100
)
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• tamoxifen treated mice that show a distended abdomen lose weight and develop a disheveled appearance and decreased mobility
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• edematous mice show an average body weight increase of 33%
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• tamoxifen treated mice that do not develop severe peripheral edema exhibit a distended abdomen, suggesting presence of ascites
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homeostasis/metabolism
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• about 2/3 of male mice treated with tamoxifen at 8 weeks of age develop peripheral edema between 21 and 28 days of tamoxifen injection
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integument
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• tamoxifen treated mice that show a distended abdomen lose weight and develop a disheveled appearance and decreased mobility
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muscle
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• in tamoxifen treated mice
• however, myocyte hypertrophy is not seen
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• both maximum and minimum dP/dt values are altered after 7 days of tamoxifen treatment, indicating a contractile defect affecting both contraction and relaxation phase of the heart beat
|
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• both maximum and minimum dP/dt values are altered after 7 days of tamoxifen treatment, indicating a contractile defect affecting both contraction and relaxation phase of the heart beat
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congestive heart failure | DOID:6000 | J:104100 | ||
