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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdr1osem1Nikr
endonuclease-mediated mutation 1, Nikolaus Rajewsky
MGI:6107169
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Cdr1osem1Nikr/Y C57BL/6N-Cdr1osem1Nikr MGI:6107177


Genotype
MGI:6107177
ot1
Allelic
Composition		 Cdr1osem1Nikr/Y
Genetic
Background		 C57BL/6N-Cdr1osem1Nikr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdr1osem1Nikr mutation (0 available); any Cdr1os mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal action potential ( J:249957 )
• altered responses to two consecutive stimuli and to a train of action potentials at 10 Hz
• stronger depression in synaptic response
increased miniature excitatory postsynaptic current frequency ( J:249957 )
• more than double frequency of spontaneous vesicle release in hippocampal neurons
• amplitude unchanged
decreased prepulse inhibition ( J:249957 )
• 30-50% reduction using 120 dB acoustic pre-pulse




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory