All Phenotypes Nyap1<tm1Tya> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nyap1^tm1Tya
targeted mutation 1, Tadashi Yamamoto
MGI:6107631

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Myo16^tm1Tya/Myo16^tm1Tya Nyap1^tm1Tya/Nyap1^tm1Tya Nyap2^tm1Tya/Nyap2^tm1Tya	B6.129P2-Nyap2^tm1Tya Nyap1^tm1Tya Myo16^tm1Tya	MGI:6107635

Allelic Composition	Myo16^tm1Tya/Myo16^tm1Tya Nyap1^tm1Tya/Nyap1^tm1Tya Nyap2^tm1Tya/Nyap2^tm1Tya
Genetic Background	B6.129P2-Nyap2^tm1Tya Nyap1^tm1Tya Myo16^tm1Tya

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo16^tm1Tya mutation (2 available); any Myo16 mutation (95 available)
Nyap1^tm1Tya mutation (2 available); any Nyap1 mutation (33 available)
Nyap2^tm1Tya mutation (2 available); any Nyap2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain size ( J:180006 )

• 83% of wild-type cortex area and thickness

• striatum

• olfactory bulb and corpus callosum

decreased brain weight ( J:180006 )

• 75% of wild-type at 3 weeks, 70% at 8 weeks

abnormal neurite morphology ( J:180006 )

• 74% of E16 wild-type total cortical neuron neurite length in culture

• E16 cortical neurons in culture refractory to neurite lengthening in presence of Contactin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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