Phenotypes associated with this allele

• Allele Symbol: Bag3^tm1.1Chen
• Allele Name: targeted mutation 1.1, Ju Chen
• Allele ID: MGI:6107852
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bag3^tm1.1Chen/Bag3^tm1.1Chen	B6.129(SJL)-Bag3^tm1.1Chen	MGI:6107908
cn2	Bag3^tm1c(EUCOMM)Hmgu/Bag3^tm1.1Chen Tg(Myhca-cre)1Abel/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N	MGI:6107910

Genotype
MGI:6107908

hm1

• Allelic Composition: Bag3^tm1.1Chen/Bag3^tm1.1Chen
• Genetic Background: B6.129(SJL)-Bag3^tm1.1Chen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Significant growth retardation in Bag3^tm1.1Chen/Bag3^tm1.1Chen (m/m) mutant mice compared with littermate control

mortality/aging

premature death ( J:246352 )

• premature lethality at 4 weeks of age

growth/size/body

postnatal growth retardation ( J:246352 )

• impaired postnatal growth

Genotype
MGI:6107910

cn2

• Allelic Composition: Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen; Tg(Myhca-cre)1Abel/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N
• Cell Lines: HEPD0556_7_B06

Cardiac enlargement in Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen Tg(Myhca-cre)1Abel/0 mice at 6 months of age

cardiovascular system

enlarged heart ( J:246352 )

• cardiac enlargement

increased heart weight ( J:246352 )

• heart weight to body weight and heart weight to tibia length ratios are increased at 5 months of age

dilated cardiomyopathy ( J:246352 )

decreased cardiac muscle contractility ( J:246352 )

• diminished systolic function

abnormal heart echocardiography feature ( J:246352 )

• diminished systolic function with mice showing reduced fractional shortening, increased left ventricle internal diameter at end diastole and increased left ventricle internal diameter at end systole

homeostasis/metabolism

impaired autophagy ( J:246352 )

• hearts exhibit impaired autophagic flux

cellular

impaired autophagy ( J:246352 )

• hearts exhibit impaired autophagic flux

muscle

dilated cardiomyopathy ( J:246352 )

decreased cardiac muscle contractility ( J:246352 )

• diminished systolic function

growth/size/body

enlarged heart ( J:246352 )

• cardiac enlargement

increased heart weight ( J:246352 )

• heart weight to body weight and heart weight to tibia length ratios are increased at 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1HH		DOID:0110448	OMIM:613881	J:246352