mortality/aging
• no embryos are recovered at E7.5 - E10.5 or E11.5 - E18.5
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Allele Symbol Allele Name Allele ID |
Copb2em1Rstot endonuclease-mediated mutation 1, Rolf W Stottmann MGI:6107885 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no embryos are recovered at E7.5 - E10.5 or E11.5 - E18.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fewer than expected mice are found at birth
• in one litter all 4 heterozygotes survived the perinatal period but were morbid at P19
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• increased cell death in the cortex, hippocampus, midbrain, cerebellum and hindbrain at P0-P3
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• neurospheres produce fewer cells in culture
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• slight but significant increase in proliferation in the neurogenic ventricular zone
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• decreased cortical area
• 32% decrease in the later-born CTIP2-positive neurons in layer V
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• typically lack a milk spot at P0 and P1
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• small and sickly at birth
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• increased cell death in the cortex, hippocampus, midbrain, cerebellum and hindbrain at P0-P3
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• neurospheres produce fewer cells in culture
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• slight but significant increase in proliferation in the neurogenic ventricular zone
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
microcephaly | DOID:10907 | J:252710 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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