All Phenotypes Hltf<tm1.1Hdin> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hltf^tm1.1Hdin
targeted mutation 1.1, Hao Ding
MGI:6108112

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apc^Min/Apc⁺ Hltf^tm1.1Hdin/Hltf^tm1.1Hdin	involves: 129 * C57BL/6 * FVB/N	MGI:6108175
cx2	Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Shprh^{Gt(RRJ453)Byg}/Shprh^{Gt(RRJ453)Byg}	involves: 129 * C57BL/6 * SJL	MGI:6108258
cx3	Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Shprh^tm1Jhjh/Shprh^tm1Jhjh	involves: 129 * C57BL/6 * SJL	MGI:6108259

Allelic Composition	Apc^Min/Apc⁺ Hltf^tm1.1Hdin/Hltf^tm1.1Hdin
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (157 available)
Hltf^tm1.1Hdin mutation (0 available); any Hltf mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:252991 )

• aneuploidy owing to nonreciprocal translocations, chromosomal fusions (dicentric chromosomes, centromeric fusions, missing telomeres) and chromosomal fragments and breaks in cultured colon tumor cells

neoplasm

neoplasm ( J:252991 )

N	• average 65 macroscopic intestine adenocarcinoma tumors per mouse, similar to wild-type • average 1.5 macroscopic colon adenocarcinoma tumors per mouse, similar to wild-type

increased metastatic potential ( J:252991 )

• invasive intestinal adenocarcinomas (deeper invasion of tumor cells into muscularis propria of small intestine)

• high beta-catenin activity in invaded neoplastic glandular cells in small intestine

• most colon tumors displayed a more severe glandular atypia resulting in formation of many mucin-filled cysts

• most colon tumors displayed strong desmoplastic stromal reaction

• higher beta-catenin activity in colon tumor cells

• transplanted colon tumor cells are malignant

Allelic Composition	Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Shprh^{Gt(RRJ453)Byg}/Shprh^{Gt(RRJ453)Byg}
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hltf^tm1.1Hdin mutation (0 available); any Hltf mutation (47 available)
Shprh^{Gt(RRJ453)Byg} mutation (0 available); any Shprh mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177630 )

N	• normal somatic hypermutation frequency and spectrum in JH4 intronic region in germinal center B cells

Allelic Composition	Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Shprh^tm1Jhjh/Shprh^tm1Jhjh
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hltf^tm1.1Hdin mutation (0 available); any Hltf mutation (47 available)
Shprh^tm1Jhjh mutation (0 available); any Shprh mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177630 )

N	• class switch recombination in primary-activated B cells • normal somatic hypermutation frequency and spectrum in JH4 intronic region in germinal center B cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24