cellular
• aneuploidy owing to nonreciprocal translocations, chromosomal fusions (dicentric chromosomes, centromeric fusions, missing telomeres) and chromosomal fragments and breaks in cultured colon tumor cells
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neoplasm
N |
• average 65 macroscopic intestine adenocarcinoma tumors per mouse, similar to wild-type
• average 1.5 macroscopic colon adenocarcinoma tumors per mouse, similar to wild-type
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• invasive intestinal adenocarcinomas (deeper invasion of tumor cells into muscularis propria of small intestine)
• high beta-catenin activity in invaded neoplastic glandular cells in small intestine
• most colon tumors displayed a more severe glandular atypia resulting in formation of many mucin-filled cysts
• most colon tumors displayed strong desmoplastic stromal reaction
• higher beta-catenin activity in colon tumor cells
• transplanted colon tumor cells are malignant
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