All Phenotypes Jak3<m1J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Jak3^m1J
mutation 1, Jackson
MGI:6108882

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak3^m1J/Jak3^m1J	B6.Cg-Crb1⁺ Jak3^m1J/Boc	MGI:6257347
cx2	Crb1^em2Boc/Crb1^em2Boc Jak3^m1J/Jak3^m1J	B6.Cg-Crb1^em2Boc Jak3^m1J/Boc	MGI:7713417
cx3	Crb1^rd8+em1Boc/Crb1^rd8+em1Boc Jak3^m1J/Jak3^m1J	B6.Cg-Crb1^rd8+em1Boc Jak3^m1J/Boc	MGI:6258407
cx4	Crb1^rd8/Crb1^rd8 Jak3^m1J/Jak3^m1J	B6.Cg-Crb1^rd8 Jak3^m1J/BocJ	MGI:6257345

Allelic Composition	Jak3^m1J/Jak3^m1J
Genetic Background	B6.Cg-Crb1⁺ Jak3^m1J/Boc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3^m1J mutation (8 available); any Jak3 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small thymus ( J:265859 )

decreased thymus weight ( J:265859 )

• at 3 months of age the average thymus weight is 10.6 mg versus 87.2 mg for wild-type controls

vision/eye

vision/eye phenotype ( J:265859 )

N	• normal retinas

hematopoietic system

small thymus ( J:265859 )

decreased thymus weight ( J:265859 )

• at 3 months of age the average thymus weight is 10.6 mg versus 87.2 mg for wild-type controls

small spleen ( J:265859 )

decreased spleen weight ( J:265859 )

• at 3 months of age the average spleen weight is 36.6 mg versus 81 mg for wild-type controls

immune system

small thymus ( J:265859 )

decreased thymus weight ( J:265859 )

• at 3 months of age the average thymus weight is 10.6 mg versus 87.2 mg for wild-type controls

small spleen ( J:265859 )

decreased spleen weight ( J:265859 )

• at 3 months of age the average spleen weight is 36.6 mg versus 81 mg for wild-type controls

Allelic Composition	Crb1^em2Boc/Crb1^em2Boc Jak3^m1J/Jak3^m1J
Genetic Background	B6.Cg-Crb1^em2Boc Jak3^m1J/Boc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb1^em2Boc mutation (2 available); any Crb1 mutation (92 available)
Jak3^m1J mutation (8 available); any Jak3 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Early-onset multifocal depigmented retinal lesions in Crb1^em2Boc/Crb1^em2Boc Jak3^m1J/Jak3^m1J mice on a C57BL/6J background (A, B) but normal retinas in Crb1^em2Boc/Crb1^em2Boc mice on a DBA/2J background (C,D).

cardiovascular system

retina neovascularization ( J:353326 )

• early-onset multifocal depigmented retinal lesions, significant by 4 weeks of age

vision/eye

retina neovascularization ( J:353326 )

• early-onset multifocal depigmented retinal lesions, significant by 4 weeks of age

Allelic Composition	Crb1^rd8+em1Boc/Crb1^rd8+em1Boc Jak3^m1J/Jak3^m1J
Genetic Background	B6.Cg-Crb1^rd8+em1Boc Jak3^m1J/Boc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb1^rd8+em1Boc mutation (1 available); any Crb1 mutation (92 available)
Jak3^m1J mutation (8 available); any Jak3 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small thymus ( J:265859 )

vision/eye

vision/eye phenotype ( J:265859 )

hematopoietic system

small thymus ( J:265859 )

small spleen ( J:265859 )

immune system

small thymus ( J:265859 )

small spleen ( J:265859 )

Allelic Composition	Crb1^rd8/Crb1^rd8 Jak3^m1J/Jak3^m1J
Genetic Background	B6.Cg-Crb1^rd8 Jak3^m1J/BocJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb1^rd8 mutation (18 available); any Crb1 mutation (92 available)
Jak3^m1J mutation (8 available); any Jak3 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal retina pigment epithelium morphology ( J:265859 )

abnormal retina pigmentation ( J:265859 )

endocrine/exocrine glands

small thymus ( J:265859 )

cardiovascular system

abnormal retina vasculature morphology ( J:265859 )

retina neovascularization ( J:265859 )

hematopoietic system

small thymus ( J:265859 )

small spleen ( J:265859 )

decreased spleen weight ( J:265859 )

immune system

small thymus ( J:265859 )

small spleen ( J:265859 )

decreased spleen weight ( J:265859 )

vision/eye

abnormal retina morphology ( J:265859 )

• at 18 days of age there are areas of retinal depigmentation lacking fluorescein leakage, the number and size of spots increases and some fluorescein leakage is found at 25 days of age, by 3 weeks of age subretinal vascularization and disturbance of the outer retina are found, and eventually the depigmented spots become large areas of depigmentation with aberrant blood vessels spaning from the retinal pigment epithelium to the inner nuclear layer accompanied by photoreceptor cell degeneration

abnormal retina vasculature morphology ( J:265859 )

retina neovascularization ( J:265859 )

abnormal retina pigment epithelium morphology ( J:265859 )

abnormal retina pigmentation ( J:265859 )

retina spots ( J:265859 )

abnormal electroretinogram waveform feature ( J:265859 )

abnormal eye electrophysiology ( J:265859 )

• electroretinograms show a slight reduction in scotopic and photopic responses at 8 weeks of age and larger reduction at 8 months of age

abnormal cone electrophysiology ( J:265859 )

abnormal rod electrophysiology ( J:265859 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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