Phenotypes associated with this allele

• Allele Symbol: Shisa9^tm1Mony
• Allele Name: targeted mutation 1, Hannah Monyer
• Allele ID: MGI:6109966
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shisa9^tm1Mony/Shisa9^tm1Mony	involves: 129	MGI:6147596
hm2	Shisa9^tm1Mony/Shisa9^tm1Mony	involves: 129 * C57BL/6	MGI:6109967

Genotype
MGI:6147596

hm1

• Allelic Composition: Shisa9^tm1Mony/Shisa9^tm1Mony
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal action potential ( J:257714 )

• decreased firing probability of relay cells with higher stimulation frequency

• increased firing rate when the optic tract is stimulated more than 4 times

• however, firing rates are normal after a short stimulus trains

abnormal excitatory postsynaptic current amplitude ( J:257714 )

• smaller reduction in EPSC amplitude at the beginning of the stimulus train than in wild-type optic nerves

• however, steady-state ESPSC amplitudes when stimulated with 10 Hz is normal

reduced AMPA-mediated synaptic currents ( J:257714 )

• reduced amplitude normalized to NMDA currents in retinogeniculate and corticogeniculate synapses compared with wild-type synapses

decreased synaptic depression ( J:257714 )

• relay neurons fail to exhibit a strong depression of EPSP amplitudes in a current-clamp mode when the optic tract is stimulated ten times at 50 Hz

enhanced paired-pulse facilitation ( J:257714 )

• of AMPAR-mediated currents in retinogeniculate synapses when stimulating the optic tract twice with different inter-stimulus intervals

• in retinogeniculate synapses stimulated with a Cs+ based solution

• however, paired pulse facilitation is normal in corticogeniculate synapses

Genotype
MGI:6109967

hm2

• Allelic Composition: Shisa9^tm1Mony/Shisa9^tm1Mony
• Genetic Background: involves: 129 * C57BL/6

nervous system

abnormal synaptic plasticity ( J:158757 )

• increased the paired-pulse ratio of AMPA currents in lateral and medial perforant path-granule cell synapses