All Phenotypes Tex19.2<tm1.2Ics> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tex19.2^tm1.2Ics
targeted mutation 1.2, Mouse Clinical Institute
MGI:6110008

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tex19.1^tm2.2Ics/Tex19.1^tm2.2Ics Tex19.2^tm1.2Ics/Tex19.2^tm1.2Ics	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:6110578

Allelic Composition	Tex19.1^tm2.2Ics/Tex19.1^tm2.2Ics Tex19.2^tm1.2Ics/Tex19.2^tm1.2Ics
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex19.1^tm2.2Ics mutation (0 available); any Tex19.1 mutation (10 available)
Tex19.2^tm1.2Ics mutation (0 available); any Tex19.2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:243444 )

• in epididymis

abnormal synaptonemal complex ( J:243444 )

• synaptic failure at pachytene stage

seminiferous tubule degeneration ( J:243444 )

• tubules contain only early spermatogenic cells, no post-meiotic germ cells

• increased level of apoptosis

decreased testis weight ( J:243444 )

• 3-fold lower weight

testis degeneration ( J:243444 )

• vacuolization and seminiferous epithelium degeneration starting between P10 and P16

arrest of spermatogenesis ( J:243444 )

• between P10 and P16

arrest of male meiosis ( J:243444 )

• persistent double-stranded breaks at pachytene stage

transmission ratio distortion ( J:243444 )

• fewer homozygous mice born than expected from heterozygote interbreeding: 207:440:59 wt:het:hom

male infertility ( J:243444 )

endocrine/exocrine glands

seminiferous tubule degeneration ( J:243444 )

• tubules contain only early spermatogenic cells, no post-meiotic germ cells

• increased level of apoptosis

decreased testis weight ( J:243444 )

• 3-fold lower weight

testis degeneration ( J:243444 )

• vacuolization and seminiferous epithelium degeneration starting between P10 and P16

mortality/aging

postnatal lethality ( J:243444 )

• fewer female than male mice survive: at 2 weeks female:male ratio is 32:68

cellular

azoospermia ( J:243444 )

• in epididymis

arrest of male meiosis ( J:243444 )

• persistent double-stranded breaks at pachytene stage

abnormal synaptonemal complex ( J:243444 )

• synaptic failure at pachytene stage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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