reproductive system
azoospermia
(
J:243444
)
• in epididymis
|
• synaptic failure at pachytene stage
|
• tubules contain only early spermatogenic cells, no post-meiotic germ cells
• increased level of apoptosis
|
• 3-fold lower weight
|
• vacuolization and seminiferous epithelium degeneration starting between P10 and P16
|
• between P10 and P16
|
• persistent double-stranded breaks at pachytene stage
|
• fewer homozygous mice born than expected from heterozygote interbreeding: 207:440:59 wt:het:hom
|
endocrine/exocrine glands
• tubules contain only early spermatogenic cells, no post-meiotic germ cells
• increased level of apoptosis
|
• 3-fold lower weight
|
• vacuolization and seminiferous epithelium degeneration starting between P10 and P16
|
mortality/aging
• fewer female than male mice survive: at 2 weeks female:male ratio is 32:68
|
cellular
azoospermia
(
J:243444
)
• in epididymis
|
• persistent double-stranded breaks at pachytene stage
|
• synaptic failure at pachytene stage
|