Phenotypes associated with this allele

• Allele Symbol: Odad4^em#Omra
• Allele Name: endonuclease-mediated mutation, Heymut Omran
• Allele ID: MGI:6110171
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Odad4^em#Omra/Odad4^em#Omra	involves: C57BL/6	MGI:6110172

Genotype
MGI:6110172

hm1

• Allelic Composition: Odad4^em#Omra/Odad4^em#Omra
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:244361 )

• fewer than expected mice are found at 2 weeks of age

embryo

absent nodal flow ( J:244361 )

• immotility of monocilia indicated by absence of normal leftward-directed flow

growth/size/body

decreased body size ( J:244361 )

• in most mice at 2 weeks of age

heterotaxia ( J:244361 )

• most mice display a variety of left-right body symmetry defects tissues affected in at least some mice include: lung, liver, heart, aortic arch, azygos vein, stomach, vena cava

lung situs inversus ( J:244361 )

• in some mice

cardiovascular system

dextrocardia ( J:244361 )

• in some mice

nervous system

hydrocephaly ( J:244361 )

• in most mice at 2 weeks of age

respiratory system

lung situs inversus ( J:244361 )

• in some mice

impaired mucociliary clearance ( J:244361 )

• slow moving tracheal cilia in some mice

cellular

absent nodal flow ( J:244361 )

• immotility of monocilia indicated by absence of normal leftward-directed flow

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 35		DOID:0110620	OMIM:617092	J:244361