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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nmbtm1Zfc
targeted mutation 1, Zhou-Feng Chen
MGI:6110562
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nmbtm1Zfc/Nmbtm1Zfc involves: 129S7/SvEvBrd * C57BL/6J MGI:6111347
cx2
 		Grptm1Jfb/Grptm1Jfb
Nmbtm1Zfc/Nmbtm1Zfc 		involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J MGI:6111348


Genotype
MGI:6111347
hm1
Allelic
Composition		 Nmbtm1Zfc/Nmbtm1Zfc
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmbtm1Zfc mutation (0 available); any Nmb mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:253572 )
N
• mice exhibit normal pain behaviors
abnormal grooming behavior ( J:253572 )
• attenuated scratching in response to histamine, compound 48/80 and 5-HT application
• however, application of chloroquine, SLIGRL and BAM8-22 resulted in normal scratching behavior




Genotype
MGI:6111348
cx2
Allelic
Composition		 Grptm1Jfb/Grptm1Jfb
Nmbtm1Zfc/Nmbtm1Zfc
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grptm1Jfb mutation (1 available); any Grp mutation (30 available)
Nmbtm1Zfc mutation (0 available); any Nmb mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:253572 )
N
• mice exhibit normal pain behaviors
abnormal grooming behavior ( J:253572 )
• attenuated scratching in response to histamine, compound 48/80, 5-HT, chloroquine, SLIGRL and BAM8-22 application

nervous system
nervous system phenotype ( J:253572 )
N
• mice exhibit normal primary afferent projections




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory