Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Bmp4,-EGFP)1Ypc
• Allele Name: transgene insertion 1, YiPing Chen
• Allele ID: MGI:6110825
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Osr2^tm2(cre)Jian/Osr2^+ Tg(CAG-Bmp4,-EGFP)1Ypc/0	involves: 129S1/Sv * C57BL/6J * CD-1	MGI:6110830
cn2	H2az2^Tg(Wnt1-cre)11Rth/H2az2^+ Tg(CAG-Bmp4,-EGFP)1Ypc/0	involves: C57BL/6J * CBA/J * CD-1	MGI:6110828

Genotype
MGI:6110830

cn1

• Allelic Composition: Osr2^tm2(cre)Jian/Osr2⁺; Tg(CAG-Bmp4,-EGFP)1Ypc/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

palatal shelves fail to meet at midline ( J:214763 )

• at the anterior level, the palatal shelves elevate but fail to contact

• however, origin of palatal shelves form the maxillary processes remains unaltered

palatal shelf fusion with tongue or mandible ( J:214763 )

• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible

cleft palate ( J:214763 )

digestive/alimentary system

palatal shelves fail to meet at midline ( J:214763 )

• at the anterior level, the palatal shelves elevate but fail to contact

• however, origin of palatal shelves form the maxillary processes remains unaltered

palatal shelf fusion with tongue or mandible ( J:214763 )

• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible

cleft palate ( J:214763 )

growth/size/body

palatal shelves fail to meet at midline ( J:214763 )

• at the anterior level, the palatal shelves elevate but fail to contact

• however, origin of palatal shelves form the maxillary processes remains unaltered

palatal shelf fusion with tongue or mandible ( J:214763 )

• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible

cleft palate ( J:214763 )

Genotype
MGI:6110828

cn2

• Allelic Composition: H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺; Tg(CAG-Bmp4,-EGFP)1Ypc/0
• Genetic Background: involves: C57BL/6J * CBA/J * CD-1

craniofacial

frontal bone hypoplasia ( J:214763 )

abnormal jaw morphology ( J:214763 )

• slight decrease of cell proliferation rate in the maxillo-mandibular junction at E12.5

• ectopic cell apoptosis in the maxillo-mandibular junction at E12.5

absent mandibular angle ( J:214763 )

absent mandibular condyloid process ( J:214763 )

absent mandibular coronoid process ( J:214763 )

abnormal temporomandibular joint morphology ( J:214763 )

• temporomandibular joint agenesis

mandible hypoplasia ( J:214763 )

maxilla hypoplasia ( J:214763 )

agnathia ( J:214763 )

syngnathia ( J:214763 )

• bony fusion of the jaws resembling congenital bony syngnathia is seen as early as E16.5

• the bony structures connecting the maxilla and mandible appear to derive from the posterior portion of the maxilla

nasal bone hypoplasia ( J:214763 )

abnormal secondary palate development ( J:214763 )

• patterning of the secondary palate is disrupted; the anterior portion of the palatal shelves do not grow out from the maxilla at E13.5, and instead, a pair of palatal shelf-like structures originating from the mandible are seen, in a reverse direction with their tip pointing dorsally toward the nasal septum

• at E16.5, the palatal shelf-like structures remain separated and pointing dorsally along the tongue at the anterior level

• the mandibular protrusions are of palatal tissue origin

decreased palatal shelf size ( J:214763 )

• palate shelves appear smaller at the posterior levels

palatal shelf fusion with tongue or mandible ( J:214763 )

• palate shelves are abnormally fused with the mandible

cleft palate ( J:214763 )

short snout ( J:214763 )

absent outer ear ( J:214763 )

cellular

enhanced osteoblast differentiation ( J:214763 )

• increase in alkaline phosphatase (ALP) activity in the mandible and maxillo-mandibular junction at E12.5 and E13.5 indicating enhanced osteoblast differentiation

digestive/alimentary system

abnormal secondary palate development ( J:214763 )

• patterning of the secondary palate is disrupted; the anterior portion of the palatal shelves do not grow out from the maxilla at E13.5, and instead, a pair of palatal shelf-like structures originating from the mandible are seen, in a reverse direction with their tip pointing dorsally toward the nasal septum

• at E16.5, the palatal shelf-like structures remain separated and pointing dorsally along the tongue at the anterior level

• the mandibular protrusions are of palatal tissue origin

decreased palatal shelf size ( J:214763 )

• palate shelves appear smaller at the posterior levels

palatal shelf fusion with tongue or mandible ( J:214763 )

• palate shelves are abnormally fused with the mandible

cleft palate ( J:214763 )

growth/size/body

nasal bone hypoplasia ( J:214763 )

abnormal secondary palate development ( J:214763 )

• patterning of the secondary palate is disrupted; the anterior portion of the palatal shelves do not grow out from the maxilla at E13.5, and instead, a pair of palatal shelf-like structures originating from the mandible are seen, in a reverse direction with their tip pointing dorsally toward the nasal septum

• at E16.5, the palatal shelf-like structures remain separated and pointing dorsally along the tongue at the anterior level

• the mandibular protrusions are of palatal tissue origin

decreased palatal shelf size ( J:214763 )

• palate shelves appear smaller at the posterior levels

palatal shelf fusion with tongue or mandible ( J:214763 )

• palate shelves are abnormally fused with the mandible

cleft palate ( J:214763 )

short snout ( J:214763 )

absent outer ear ( J:214763 )

hearing/vestibular/ear

absent outer ear ( J:214763 )

skeleton

enhanced osteoblast differentiation ( J:214763 )

• increase in alkaline phosphatase (ALP) activity in the mandible and maxillo-mandibular junction at E12.5 and E13.5 indicating enhanced osteoblast differentiation

frontal bone hypoplasia ( J:214763 )

abnormal jaw morphology ( J:214763 )

• slight decrease of cell proliferation rate in the maxillo-mandibular junction at E12.5

• ectopic cell apoptosis in the maxillo-mandibular junction at E12.5

absent mandibular angle ( J:214763 )

absent mandibular condyloid process ( J:214763 )

absent mandibular coronoid process ( J:214763 )

abnormal temporomandibular joint morphology ( J:214763 )

• temporomandibular joint agenesis

mandible hypoplasia ( J:214763 )

maxilla hypoplasia ( J:214763 )

agnathia ( J:214763 )

syngnathia ( J:214763 )

• bony fusion of the jaws resembling congenital bony syngnathia is seen as early as E16.5

• the bony structures connecting the maxilla and mandible appear to derive from the posterior portion of the maxilla

nasal bone hypoplasia ( J:214763 )

vision/eye

eyelids open at birth ( J:214763 )

respiratory system

nasal bone hypoplasia ( J:214763 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cleft palate-lateral synechia syndrome		DOID:0080313	OMIM:119550	J:214763