All Phenotypes Tent5c<em1Adki> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tent5c^em1Adki/Tent5c^em1Adki	involves: C57BL/6JTar * CBA/WTar	MGI:6111078
cx2	Tent5b^em1Adki/Tent5b^em1Adki Tent5c^em1Adki/Tent5c^em1Adki	involves: C57BL/6JTar * CBA/WTar	MGI:8164375

Allelic Composition	Tent5c^em1Adki/Tent5c^em1Adki
Genetic Background	involves: C57BL/6JTar * CBA/WTar

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tent5c^em1Adki mutation (0 available); any Tent5c mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell proliferation ( J:252302 )

hypochromic microcytic anemia ( J:252302 )

increased erythrocyte cell number ( J:252302 )

decreased hemoglobin content ( J:252302 )

decreased mean corpuscular hemoglobin concentration ( J:252302 )

decreased mean corpuscular volume ( J:252302 )

immune system

decreased B cell proliferation ( J:252302 )

reproductive system

decreased male germ cell number ( J:360869 )

• males produce, on average, fewer total germ cells but accumulate more ES in the lumen of seminiferous tubules

increased male germ cell apoptosis ( J:360869 )

• male germ cells grown in culture exhibit higher mortality than wild-type germ cells

abnormal spermatogenesis ( J:360869 )

abnormal sperm head morphology ( J:360869 )

• high rate of head or DNA material loss in sperm isolated from the epididymis

arrest of male meiosis ( J:360869 )

• germ cell progression through meiosis is hindered

• germ cell content at 3, 4, 7, 10, and 15 weeks of age shows that the ratio of germ cell populations remains stable throughout this time unlike in wild-type males which show that primary spermatocytes diminish and rapid growth of spermatids and spermatozoa is seen

male infertility ( J:360869 )

cellular

abnormal sperm head morphology ( J:360869 )

• high rate of head or DNA material loss in sperm isolated from the epididymis

decreased male germ cell number ( J:360869 )

• males produce, on average, fewer total germ cells but accumulate more ES in the lumen of seminiferous tubules

arrest of male meiosis ( J:360869 )

• germ cell progression through meiosis is hindered

increased male germ cell apoptosis ( J:360869 )

• male germ cells grown in culture exhibit higher mortality than wild-type germ cells

decreased B cell proliferation ( J:252302 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

oocyte degeneration ( J:360869 )

• degeneration of preovulatory prophase I oocytes

increased female germ cell apoptosis ( J:360869 )

increased ovary apoptosis ( J:360869 )

• ovaries show high levels of apoptosis, not only within oocytes but also in surrounding granulosa cells

increased granulosa cell apoptosis ( J:360869 )

abnormal oogenesis ( J:360869 )

• early oogenesis arrest, with degeneration of preovulatory prophase I oocytes

• 8-week-old ovaries show oocytes in various stages of degeneration and cell death

• 5-week-old ovaries have oocytes that show initial signs of degeneration, with 35% of oocytes remaining in the living state and the remainder showing various abnormalities

endocrine/exocrine glands

increased ovary apoptosis ( J:360869 )

• ovaries show high levels of apoptosis, not only within oocytes but also in surrounding granulosa cells

increased granulosa cell apoptosis ( J:360869 )

absent corpus luteum ( J:360869 )

• the presence of corpora lutea (indicating previous ovulation) are not seen

absent tertiary ovarian follicles ( J:360869 )

• mature antral follicles ready for ovulation are not seen

impaired ovarian folliculogenesis ( J:360869 )

• smaller ovaries with arrest of follicular growth at the early antral stage and no sighs of significant follicular growth

• ovarian follicle growth cannot be restored by hormonal stimulation with pregnant mates serum gonadotropin (PMSG) or human chorionic gonadotropin (hCG)

small ovary ( J:360869 )

• smaller ovaries with no sighs of significant follicular growth or earlier ovulation

reproductive system

oocyte degeneration ( J:360869 )

• degeneration of preovulatory prophase I oocytes

increased female germ cell apoptosis ( J:360869 )

increased ovary apoptosis ( J:360869 )

• ovaries show high levels of apoptosis, not only within oocytes but also in surrounding granulosa cells

increased granulosa cell apoptosis ( J:360869 )

abnormal oogenesis ( J:360869 )

• early oogenesis arrest, with degeneration of preovulatory prophase I oocytes

• 8-week-old ovaries show oocytes in various stages of degeneration and cell death

• 5-week-old ovaries have oocytes that show initial signs of degeneration, with 35% of oocytes remaining in the living state and the remainder showing various abnormalities

absent corpus luteum ( J:360869 )

• the presence of corpora lutea (indicating previous ovulation) are not seen

absent tertiary ovarian follicles ( J:360869 )

• mature antral follicles ready for ovulation are not seen

impaired ovarian folliculogenesis ( J:360869 )

• smaller ovaries with arrest of follicular growth at the early antral stage and no sighs of significant follicular growth

• ovarian follicle growth cannot be restored by hormonal stimulation with pregnant mates serum gonadotropin (PMSG) or human chorionic gonadotropin (hCG)

small ovary ( J:360869 )

• smaller ovaries with no sighs of significant follicular growth or earlier ovulation

anovulation ( J:360869 )

• no ovulation

• ovulation cannot be restored by hormonal stimulation with pregnant mates serum gonadotropin (PMSG) or human chorionic gonadotropin (hCG)

female infertility ( J:360869 )

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