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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myo9atm1.2Bah
targeted mutation 1.2, Martin Bahler
MGI:6111331
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myo9atm1.2Bah/Myo9atm1.2Bah involves: C57BL/6 * SJL MGI:6120521
cx2
Myo9atm1.2Bah/Myo9atm1.2Bah
Rhobtm1Gcp/Rhobtm1Gcp
involves: 129/Sv * C57BL/6 * SJL MGI:6120522


Genotype
MGI:6120521
hm1
Allelic
Composition
Myo9atm1.2Bah/Myo9atm1.2Bah
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo9atm1.2Bah mutation (0 available); any Myo9a mutation (114 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• hopping and trembling

embryo
• disorganized ependymal cells lining ventral caudal 3rd ventricle
• absent ependymal cells lining ventral caudal 3rd ventricle in areas of ventricle closure
• undulated appearance: distorted overall outline of ependymal cells marked by adherens junctions, with bent and strained cell-cell boundaries, first observed at P0.5
• single layer of ependymal cells transformed into multilayer configuration at multiple sites
• disordered mature ependymal epithelial cells form amorphous accumulations of cells obstructing ventricular passage
• significant reduction in number of mature multiciliated ependymal cells in ventral caudal 3rd ventricle

growth/size/body

nervous system
N
• subarachnoid space and 4th ventricle morphology
• disorganized ependymal cells lining ventral caudal 3rd ventricle
• absent ependymal cells lining ventral caudal 3rd ventricle in areas of ventricle closure
• undulated appearance: distorted overall outline of ependymal cells marked by adherens junctions, with bent and strained cell-cell boundaries, first observed at P0.5
• single layer of ependymal cells transformed into multilayer configuration at multiple sites
• disordered mature ependymal epithelial cells form amorphous accumulations of cells obstructing ventricular passage
• significant reduction in number of mature multiciliated ependymal cells in ventral caudal 3rd ventricle
• highly dilated
• distorted and closed ventral caudal 3rd ventricle
• highly dilated rostral to closed region of aqueduct
• at ventral caudal 3rd ventricle
• disordered mature ependymal epithelial cells form amorphous accumulations of cells obstructing ventricular passage
• discontinuities with denudations of ependymal epithelial layer in median aqueduct, especially in vaults
• generally asymmetric and distorted bilobed canal at dorsal side of rostral aqueduct
• partially closed, forming two separate small lumens lined by ependymal epithelial cells
• undulated appearance: distorted overall outline of ependymal cells marked by adherens junctions, with bent and strained cell-cell boundaries, first observed at P0.5
• single layer of ependymal cells transformed into multilayer configuration at multiple sites
• becomes progressively narrower and ultimately closes (stenosis) between P0.5 and P14.5
• significant reduction in number of mature multiciliated ependymal cells in rostral aqueduct

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
obstructive hydrocephalus DOID:14159 J:251454




Genotype
MGI:6120522
cx2
Allelic
Composition
Myo9atm1.2Bah/Myo9atm1.2Bah
Rhobtm1Gcp/Rhobtm1Gcp
Genetic
Background
involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo9atm1.2Bah mutation (0 available); any Myo9a mutation (114 available)
Rhobtm1Gcp mutation (0 available); any Rhob mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory