All Phenotypes Diaph1<M1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Diaph1^M1Btlr
mutation 1, Bruce Beutler
MGI:6113373

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Diaph1^M1Btlr/Diaph1^M1Btlr	C57BL/6J-Diaph1^M1Btlr	MGI:6113375
ht2	Diaph1^M1Btlr/Diaph1⁺	C57BL/6J-Diaph1^M1Btlr	MGI:6113376

Allelic Composition	Diaph1^M1Btlr/Diaph1^M1Btlr
Genetic Background	C57BL/6J-Diaph1^M1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1^M1Btlr mutation (0 available); any Diaph1 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:254820 )

• after MCMV infection

immune system

abnormal CD4-positive, alpha-beta T cell number ( J:254820 )

increased central memory CD4-positive, alpha-beta T cell number ( J:254820 )

abnormal CD8-positive, alpha-beta T cell number ( J:254820 )

• before and after MCMV infection

increased central memory CD8 positive, alpha-beta T cell number ( J:254820 )

decreased effector memory CD8-positive, alpha-beta T cell number ( J:254820 )

• after mouse cytomegalovirus (MCMV) infection

decreased IgE level ( J:254820 )

• after ovalbumin-alum administration

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:254820 )

• after MCMV infection

hematopoietic system

abnormal CD4-positive, alpha-beta T cell number ( J:254820 )

increased central memory CD4-positive, alpha-beta T cell number ( J:254820 )

abnormal CD8-positive, alpha-beta T cell number ( J:254820 )

• before and after MCMV infection

increased central memory CD8 positive, alpha-beta T cell number ( J:254820 )

decreased effector memory CD8-positive, alpha-beta T cell number ( J:254820 )

• after mouse cytomegalovirus (MCMV) infection

decreased IgE level ( J:254820 )

• after ovalbumin-alum administration

Allelic Composition	Diaph1^M1Btlr/Diaph1⁺
Genetic Background	C57BL/6J-Diaph1^M1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1^M1Btlr mutation (0 available); any Diaph1 mutation (116 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD4-positive, alpha-beta T cell number ( J:254820 )

increased central memory CD4-positive, alpha-beta T cell number ( J:254820 )

abnormal CD8-positive, alpha-beta T cell number ( J:254820 )

increased central memory CD8 positive, alpha-beta T cell number ( J:254820 )

decreased IgE level ( J:254820 )

• after ovalbumin-alum administration

immune system

abnormal CD4-positive, alpha-beta T cell number ( J:254820 )

increased central memory CD4-positive, alpha-beta T cell number ( J:254820 )

abnormal CD8-positive, alpha-beta T cell number ( J:254820 )

increased central memory CD8 positive, alpha-beta T cell number ( J:254820 )

decreased IgE level ( J:254820 )

• after ovalbumin-alum administration

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