Phenotypes associated with this allele

• Allele Symbol: Nfkb1^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:6113387
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkb1^m2Btlr/Nfkb1^m2Btlr	C57BL/6J-Nfkb1^m2Btlr	MGI:6113389
ht2	Nfkb1^m2Btlr/Nfkb1^+	C57BL/6J-Nfkb1^m2Btlr	MGI:6113390

Genotype
MGI:6113389

hm1

• Allelic Composition: Nfkb1^m2Btlr/Nfkb1^m2Btlr
• Genetic Background: C57BL/6J-Nfkb1^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased central memory CD4-positive, alpha-beta T cell number ( J:254822 )

decreased effector memory CD4-positive, alpha-beta T cell number ( J:254822 )

increased central memory CD8 positive, alpha-beta T cell number ( J:254822 )

decreased CD8-positive, naive alpha-beta T cell number ( J:254822 )

abnormal humoral immune response ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgE level ( J:254822 )

decreased IgG level ( J:254822 )

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgM level ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization

hematopoietic system

decreased central memory CD4-positive, alpha-beta T cell number ( J:254822 )

decreased effector memory CD4-positive, alpha-beta T cell number ( J:254822 )

increased central memory CD8 positive, alpha-beta T cell number ( J:254822 )

decreased CD8-positive, naive alpha-beta T cell number ( J:254822 )

decreased IgE level ( J:254822 )

decreased IgG level ( J:254822 )

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgM level ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization

Genotype
MGI:6113390

ht2

• Allelic Composition: Nfkb1^m2Btlr/Nfkb1⁺
• Genetic Background: C57BL/6J-Nfkb1^m2Btlr

hematopoietic system

decreased central memory CD4-positive, alpha-beta T cell number ( J:254822 )

decreased effector memory CD4-positive, alpha-beta T cell number ( J:254822 )

decreased IgM level ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization

immune system

decreased central memory CD4-positive, alpha-beta T cell number ( J:254822 )

decreased effector memory CD4-positive, alpha-beta T cell number ( J:254822 )

abnormal humoral immune response ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization

decreased IgM level ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization