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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pax5m3Btlr
mutation 3, Bruce Beutler
MGI:6113407
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pax5m3Btlr/Pax5m3Btlr C57BL/6J-Pax5m3Btlr MGI:6113409
ht2
 		Pax5m3Btlr/Pax5+ C57BL/6J-Pax5m3Btlr MGI:6113410


Genotype
MGI:6113409
hm1
Allelic
Composition		 Pax5m3Btlr/Pax5m3Btlr
Genetic
Background		 C57BL/6J-Pax5m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax5m3Btlr mutation (0 available); any Pax5 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:254825 )
• slight reduced frequencies of total, IgD+, IgM+ B cells in the peripheral blood
abnormal humoral immune response ( J:254825 )
• reduced response to ovalbumin administered with aluminum hydroxide, recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) and 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased IgG level ( J:254825 )
• in response to valbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:254825 )
• in response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
decreased B cell number ( J:254825 )
• slight reduced frequencies of total, IgD+, IgM+ B cells in the peripheral blood
decreased IgG level ( J:254825 )
• in response to valbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:254825 )
• in response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:6113410
ht2
Allelic
Composition		 Pax5m3Btlr/Pax5+
Genetic
Background		 C57BL/6J-Pax5m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax5m3Btlr mutation (0 available); any Pax5 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:254825 )
• slight reduced frequencies of total, IgD+, IgM+ B cells in the peripheral blood

immune system
decreased B cell number ( J:254825 )
• slight reduced frequencies of total, IgD+, IgM+ B cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory