Phenotypes associated with this allele

• Allele Symbol: Itk^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:6113416
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itk^m2Btlr/Itk^m2Btlr	C57BL/6J-Itk^m2Btlr	MGI:6113419

Genotype
MGI:6113419

hm1

• Allelic Composition: Itk^m2Btlr/Itk^m2Btlr
• Genetic Background: C57BL/6J-Itk^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B cell number ( J:254826 )

• total B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254826 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254826 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254826 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254826 )

• in the peripheral blood

decreased CD8-positive, alpha-beta memory T cell number ( J:254826 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254826 )

• in the peripheral blood

immune system

increased B cell number ( J:254826 )

• total B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254826 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254826 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254826 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254826 )

• in the peripheral blood

decreased CD8-positive, alpha-beta memory T cell number ( J:254826 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254826 )

• in the peripheral blood