Phenotypes associated with this allele

• Allele Symbol: Zap70^m6Btlr
• Allele Name: mutation 6, Bruce Beutler
• Allele ID: MGI:6113448
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zap70^m6Btlr/Zap70^m6Btlr	C57BL/6J-Zap70^m6Btlr	MGI:6113451

Genotype
MGI:6113451

hm1

• Allelic Composition: Zap70^m6Btlr/Zap70^m6Btlr
• Genetic Background: C57BL/6J-Zap70^m6Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell number ( J:254831 )

• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254831 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

abnormal humoral immune response ( J:254831 )

• reduced T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

decreased IgG level ( J:254831 )

• reduced T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

hematopoietic system

increased B cell number ( J:254831 )

• B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254831 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:254831 )

• in the peripheral blood

decreased IgG level ( J:254831 )

• reduced T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished