Phenotypes associated with this allele

• Allele Symbol: Zap70^m7Btlr
• Allele Name: mutation7, Bruce Beutler
• Allele ID: MGI:6113455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zap70^m7Btlr/Zap70^m7Btlr	C57BL/6J-Zap70^m7Btlr	MGI:6113457

Genotype
MGI:6113457

hm1

• Allelic Composition: Zap70^m7Btlr/Zap70^m7Btlr
• Genetic Background: C57BL/6J-Zap70^m7Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254832 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254832 )

• in the peripheral blood

abnormal humoral immune response ( J:254832 )

• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgG level ( J:254832 )

• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254832 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254832 )

• in the peripheral blood

decreased IgG level ( J:254832 )

• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)