All Phenotypes Themis<m3Btlr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Themis^m3Btlr
mutation 3, Bruce Beutler
MGI:6113462

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Themis^m3Btlr/Themis^m3Btlr	C57BL/6J-Themis^m3Btlr	MGI:6113464

Allelic Composition	Themis^m3Btlr/Themis^m3Btlr
Genetic Background	C57BL/6J-Themis^m3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themis^m3Btlr mutation (0 available); any Themis mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254834 )

• in the peripheral blood

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254834 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

decreased CD8-positive, alpha-beta memory T cell number ( J:254834 )

• in the peripheral blood

increased CD8-positive, alpha-beta memory T cell number ( J:254834 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254834 )

• in the peripheral blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:254834 )

• in the peripheral blood

hematopoietic system

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254834 )

• in the peripheral blood

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254834 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

decreased CD8-positive, alpha-beta memory T cell number ( J:254834 )

• in the peripheral blood

increased CD8-positive, alpha-beta memory T cell number ( J:254834 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254834 )

• in the peripheral blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:254834 )

• in the peripheral blood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24