All Phenotypes Themis<m3Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Themis^m3Btlr
mutation 3, Bruce Beutler
MGI:6113462

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Themis^m3Btlr/Themis^m3Btlr	C57BL/6J-Themis^m3Btlr	MGI:6113464

Allelic Composition	Themis^m3Btlr/Themis^m3Btlr
Genetic Background	C57BL/6J-Themis^m3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themis^m3Btlr mutation (0 available); any Themis mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254834 )

• in the peripheral blood

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254834 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

decreased CD8-positive, alpha-beta memory T cell number ( J:254834 )

• in the peripheral blood

increased CD8-positive, alpha-beta memory T cell number ( J:254834 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254834 )

• in the peripheral blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:254834 )

• in the peripheral blood

hematopoietic system

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254834 )

• in the peripheral blood

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:254834 )

• in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

decreased CD8-positive, alpha-beta memory T cell number ( J:254834 )

• in the peripheral blood

increased CD8-positive, alpha-beta memory T cell number ( J:254834 )

• in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:254834 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:254834 )

• in the peripheral blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:254834 )

• in the peripheral blood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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