Phenotypes associated with this allele

• Allele Symbol: Trp53bp1^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:6113484
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53bp1^m2Btlr/Trp53bp1^m2Btlr	C57BL/6J-Trp53bp1^m2Btlr	MGI:6113486

Genotype
MGI:6113486

hm1

• Allelic Composition: Trp53bp1^m2Btlr/Trp53bp1^m2Btlr
• Genetic Background: C57BL/6J-Trp53bp1^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:254841 )

• percentage of IgD+ B cells

increased central memory CD4-positive, alpha-beta T cell number ( J:254841 )

decreased CD8-positive, naive alpha-beta T cell number ( J:254841 )

decreased IgD level ( J:254841 )

• IgD expression on peripheral blood B cells

decreased IgG level ( J:254841 )

• decreased T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

impaired humoral immune response ( J:254841 )

• decreased T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system

decreased B cell number ( J:254841 )

• percentage of IgD+ B cells

increased central memory CD4-positive, alpha-beta T cell number ( J:254841 )

decreased CD8-positive, naive alpha-beta T cell number ( J:254841 )

decreased IgD level ( J:254841 )

• IgD expression on peripheral blood B cells

decreased IgG level ( J:254841 )

• decreased T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)