All Phenotypes Cdk20<tm1.1Jegg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg	involves: 129S7/SvEvBrd * FVB/N	MGI:6113530
cx2	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli2^tm1Alj/Gli2^tm1Alj	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N	MGI:6113534
cx3	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Smo^tm1Amc/Smo^tm1Amc	involves: 129S7/SvEvBrd * 129X1/SvJ * FVB/N	MGI:6113533
cx4	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli3^Xt-J/Gli3^Xt-J	involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N	MGI:6113536
cx5	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli3^Xt-J/Gli3⁺	involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N	MGI:6113537
cx6	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Rab23^opb2/Rab23^opb2	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:6113531

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal dorsal-ventral axis patterning ( J:243907 )

• dorsalized phenotype at the 10-13 somite stage that is partially recovered by the 45-47 somite stage

abnormal neural tube morphology ( J:243907 )

• P3 interneuron progenitors flanking the floor plate are reduced in number and located ectopically in the ventral midline

• the motor neuron progenitor domain expands ventrally across the midline at E11.5

abnormal embryonic neuroepithelium primary cilium morphology ( J:243907 )

• short, swollen morphology

abnormal floor plate morphology ( J:243907 )

• lack of midbrain furrow at E9.5 indicating a failure to specify the most ventral floor plate cells

absent floor plate ( J:243907 )

open neural tube ( J:243907 )

craniofacial

cleft palate ( J:243907 )

limbs/digits/tail

preaxial polydactyly ( J:243907 )

• mild

abnormal radius morphology ( J:243907 )

• achondroplasia of the radius and ulna

abnormal ulna morphology ( J:243907 )

• achondroplasia of the radius and ulna

vision/eye

abnormal retina pigment epithelium morphology ( J:243907 )

• reduced

cellular

abnormal cilium morphology ( J:243907 )

• cilia on MEFs show a broader distribution of lengths

abnormal embryonic neuroepithelium primary cilium morphology ( J:243907 )

• short, swollen morphology

abnormal primary cilium physiology ( J:243907 )

• expression analysis indicates a defect in intraflagellar transport in cilia on MEFs

nervous system

abnormal neural tube morphology ( J:243907 )

• P3 interneuron progenitors flanking the floor plate are reduced in number and located ectopically in the ventral midline

• the motor neuron progenitor domain expands ventrally across the midline at E11.5

abnormal embryonic neuroepithelium primary cilium morphology ( J:243907 )

• short, swollen morphology

abnormal floor plate morphology ( J:243907 )

• lack of midbrain furrow at E9.5 indicating a failure to specify the most ventral floor plate cells

absent floor plate ( J:243907 )

open neural tube ( J:243907 )

exencephaly ( J:243907 )

digestive/alimentary system

cleft palate ( J:243907 )

growth/size/body

cleft palate ( J:243907 )

skeleton

abnormal radius morphology ( J:243907 )

• achondroplasia of the radius and ulna

abnormal ulna morphology ( J:243907 )

• achondroplasia of the radius and ulna

pigmentation

abnormal retina pigment epithelium morphology ( J:243907 )

• reduced

Allelic Composition	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli2^tm1Alj/Gli2^tm1Alj
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk20^tm1.1Jegg mutation (0 available); any Cdk20 mutation (10 available)
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal dorsal-ventral axis patterning ( J:243907 )

• more dramatic dorsalization of neural tube progenitor identity than in either single mutant

abnormal neural tube morphology ( J:243907 )

• more dramatic dorsalization of neural tube progenitor identity than in either single mutant

nervous system

abnormal neural tube morphology ( J:243907 )

• more dramatic dorsalization of neural tube progenitor identity than in either single mutant

Allelic Composition	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Smo^tm1Amc/Smo^tm1Amc
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk20^tm1.1Jegg mutation (0 available); any Cdk20 mutation (10 available)
Smo^tm1Amc mutation (1 available); any Smo mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal precursor cell number ( J:243907 )

• partial restoration of some Shh-dependent cell types in the neural tubes of double mutants compared to mice homozygous null for Smo alone

Allelic Composition	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk20^tm1.1Jegg mutation (0 available); any Cdk20 mutation (10 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:243907 )

N	• restoration of floor plate patterning

Allelic Composition	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:243907 )

• variable rescue of floor plate specification

nervous system

abnormal neural tube morphology ( J:243907 )

• variable rescue of floor plate specification

Allelic Composition	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Rab23^opb2/Rab23^opb2
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk20^tm1.1Jegg mutation (0 available); any Cdk20 mutation (10 available)
Rab23^opb2 mutation (0 available); any Rab23 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:243907 )

• P3 interneuron progenitors flanking the floor plate are reduced in number

absent floor plate ( J:243907 )

• at E10.5

• similar to mice homozygous null for Cdk20 alone

nervous system

abnormal neural tube morphology ( J:243907 )

• P3 interneuron progenitors flanking the floor plate are reduced in number

absent floor plate ( J:243907 )

• at E10.5

• similar to mice homozygous null for Cdk20 alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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