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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k8M4Btlr
mutation 4, Bruce Beutler
MGI:6113556
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k8M4Btlr/Map3k8M4Btlr C57BL/6J-Map3k8M4Btlr MGI:6113558
ht2
 		Map3k8M4Btlr/Map3k8+ C57BL/6J-Map3k8M4Btlr MGI:6113559


Genotype
MGI:6113558
hm1
Allelic
Composition		 Map3k8M4Btlr/Map3k8M4Btlr
Genetic
Background		 C57BL/6J-Map3k8M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8M4Btlr mutation (0 available); any Map3k8 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254880 )
• reduced TNFalpha secretion in response to the Toll-like receptor ligand lipopolysaccharide




Genotype
MGI:6113559
ht2
Allelic
Composition		 Map3k8M4Btlr/Map3k8+
Genetic
Background		 C57BL/6J-Map3k8M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8M4Btlr mutation (0 available); any Map3k8 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254880 )
• reduced TNFalpha secretion in response to the Toll-like receptor ligand lipopolysaccharide




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory