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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tniktm1Teya
targeted mutation 1, Tesshi Yamada
MGI:6113591
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tniktm1Teya/Tniktm1Teya involves: C57BL/6J MGI:6113598
cx2
 		ApcMin/Apc+
Tniktm1Teya/Tniktm1Teya 		involves: C57BL/6J MGI:6113599


Genotype
MGI:6113598
hm1
Allelic
Composition		 Tniktm1Teya/Tniktm1Teya
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tniktm1Teya mutation (0 available); any Tnik mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:241611 )

homeostasis/metabolism
decreased circulating cholesterol level ( J:241611 )
• total serum cholesterol levels are decreased
decreased incidence of tumors by chemical induction ( J:241611 )
• mice develop fewer colon tumors after administration of the carcinogen azoxymethane (AOM)

neoplasm
decreased incidence of tumors by chemical induction ( J:241611 )
• mice develop fewer colon tumors after administration of the carcinogen azoxymethane (AOM)




Genotype
MGI:6113599
cx2
Allelic
Composition		 ApcMin/Apc+
Tniktm1Teya/Tniktm1Teya
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Tniktm1Teya mutation (0 available); any Tnik mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased alimentary system tumor incidence ( J:241611 )
• mice develop significantly lower number of tumors in the small intestine and colon than single ApcMin heterozygous mice

neoplasm
decreased alimentary system tumor incidence ( J:241611 )
• mice develop significantly lower number of tumors in the small intestine and colon than single ApcMin heterozygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory