Phenotypes associated with this allele

• Allele Symbol: Tmem35a^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:6113597
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Tmem35a^tm1.1(KOMP)Vlcg/Y	B6(FVB)-Tmem35a^tm1.1(KOMP)Vlcg	MGI:6113676

Genotype
MGI:6113676

ot1

• Allelic Composition: Tmem35a^{tm1.1(KOMP)Vlcg}/Y
• Genetic Background: B6(FVB)-Tmem35a^{tm1.1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:244268 )

N • corticosterone response to 30-minute restraint stress test

N • short term spatial reference memory: recalling escape hole location during training in Barnes maze

abnormal conditioned emotional response ( J:244268 )

• absent acoustic startle reflex after conditioning with tone-shock pairings

impaired contextual conditioning behavior ( J:244268 )

• reduced fear expression when placed in shock-paired context 24 h after training

• fear expression when placed in shock-paired context shortly after training

impaired cued conditioning behavior ( J:244268 )

• absent acoustic startle reflex after conditioning with tone-shock pairings

abnormal long-term spatial reference memory ( J:244268 )

• deficits in recalling escape hole location 24 h after final training session in Barnes maze

increased anxiety-related response ( J:244268 )

• fewer entries into open arms of elevated plus maze

decreased fear-related response ( J:244268 )

• absent acoustic startle reflex after conditioning with tone-shock pairings

• reduced fear expression when placed in shock-paired context 24 hours after training

increased locomotor activity ( J:244268 )

• increased locomotion within open field in open field test

• increased locomotion while exploring Barnes maze

nervous system

nervous system phenotype ( J:244268 )

N • hippocampus morphology according to Thy1-YFP marker staining

N • evoked post-synaptic potentials across a range of stimulus intensities or paired-pulse intervals at Schaffer collateral-CA1 synapses

reduced long-term potentiation ( J:244268 )

• significant decrease in NMDA receptor-mediated evoked postsynaptic potential (EPSP) at Schaffer collateral-CA1 synapses

growth/size/body

growth/size/body region phenotype ( J:244268 )

N • body weight

spleen hyperplasia ( J:244268 )

hematopoietic system

spleen hyperplasia ( J:244268 )

homeostasis/metabolism

increased circulating corticosterone level ( J:244268 )

• in serum

immune system

spleen hyperplasia ( J:244268 )

endocrine/exocrine glands

adrenal gland hyperplasia ( J:244268 )