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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myd88M4Btlr
mutation 4, Bruce Beutler
MGI:6113640
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myd88M4Btlr/Myd88M4Btlr C57BL/6J-Myd88M4Btlr MGI:6113642
ht2
 		Myd88M4Btlr/Myd88+ C57BL/6J-Myd88M4Btlr MGI:6113643


Genotype
MGI:6113642
hm1
Allelic
Composition		 Myd88M4Btlr/Myd88M4Btlr
Genetic
Background		 C57BL/6J-Myd88M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88M4Btlr mutation (0 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254917 )
• reduced TNF secretion in response to the TLR9 ligand CpG oligodeoxynucleotides (CpG ODN) primed with IFN and the TLR7 ligand R848




Genotype
MGI:6113643
ht2
Allelic
Composition		 Myd88M4Btlr/Myd88+
Genetic
Background		 C57BL/6J-Myd88M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88M4Btlr mutation (0 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254917 )
• reduced TNF secretion in response to the TLR9 ligand CpG oligodeoxynucleotides (CpG ODN) primed with IFN and the TLR7 ligand R848




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory