About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myd88M4Btlr
mutation 4, Bruce Beutler
MGI:6113640
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myd88M4Btlr/Myd88M4Btlr C57BL/6J-Myd88M4Btlr MGI:6113642
ht2
 		Myd88M4Btlr/Myd88+ C57BL/6J-Myd88M4Btlr MGI:6113643


Genotype
MGI:6113642
hm1
Allelic
Composition		 Myd88M4Btlr/Myd88M4Btlr
Genetic
Background		 C57BL/6J-Myd88M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88M4Btlr mutation (0 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254917 )
• reduced TNF secretion in response to the TLR9 ligand CpG oligodeoxynucleotides (CpG ODN) primed with IFN and the TLR7 ligand R848




Genotype
MGI:6113643
ht2
Allelic
Composition		 Myd88M4Btlr/Myd88+
Genetic
Background		 C57BL/6J-Myd88M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88M4Btlr mutation (0 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254917 )
• reduced TNF secretion in response to the TLR9 ligand CpG oligodeoxynucleotides (CpG ODN) primed with IFN and the TLR7 ligand R848




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory