About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr3M2Btlr
mutation 2, Bruce Beutler
MGI:6113649
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr3M2Btlr/Tlr3M2Btlr C57BL/6J-Tlr3M2Btlr MGI:6113651
ht2
 		Tlr3M2Btlr/Tlr3+ C57BL/6J-Tlr3M2Btlr MGI:6113652


Genotype
MGI:6113651
hm1
Allelic
Composition		 Tlr3M2Btlr/Tlr3M2Btlr
Genetic
Background		 C57BL/6J-Tlr3M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr3M2Btlr mutation (0 available); any Tlr3 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254925 )
• decreased TNFalpha secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C) and priming with IFNgamma




Genotype
MGI:6113652
ht2
Allelic
Composition		 Tlr3M2Btlr/Tlr3+
Genetic
Background		 C57BL/6J-Tlr3M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr3M2Btlr mutation (0 available); any Tlr3 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:254925 )
• decreased TNFalpha secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C) and priming with IFNgamma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory