Phenotypes associated with this allele

• Allele Symbol: Pcp4^tm1.1Kzy
• Allele Name: targeted mutation 1.1, Kazuhiro Yamakawa
• Allele ID: MGI:6113653
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcp4^tm1.1Kzy/Pcp4^tm1.1Kzy	involves: FVB/N	MGI:6113654
cx2	Dp(16Cbr1-Fam3b)1Rhr/0 Pcp4^tm1.1Kzy/Pcp4^+	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:6113678

Genotype
MGI:6113654

hm1

• Allelic Composition: Pcp4^tm1.1Kzy/Pcp4^tm1.1Kzy
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal lateral ventricle morphology ( J:241597 )

• lateral ventricles of the brain are smaller in volume

Genotype
MGI:6113678

cx2

• Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0; Pcp4^tm1.1Kzy/Pcp4⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

cellular

abnormal brain ependyma motile cilium physiology ( J:241597 )

• mice show rescue of the decreased cilia beating frequency and cilia beating angle seen in Dp(16Cbr1-Fam32b)1Rhr/0 mice to a level slightly, yet significantly, higher than in wild-type mice

nervous system

abnormal brain ependyma motile cilium physiology ( J:241597 )

• mice show rescue of the decreased cilia beating frequency and cilia beating angle seen in Dp(16Cbr1-Fam32b)1Rhr/0 mice to a level slightly, yet significantly, higher than in wild-type mice

increased brain size ( J:241597 )

• rescue of whole brain enlargement is not seen

• lateral ventricles and the dorsal third ventricle are smaller than in Dp(16Cbr1-Fam32b)1Rhr mice and similar in size to wild-type mice