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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcp4tm1.1Kzy
targeted mutation 1.1, Kazuhiro Yamakawa
MGI:6113653
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pcp4tm1.1Kzy/Pcp4tm1.1Kzy involves: FVB/N MGI:6113654
cx2
 		Dp(16Cbr1-Fam3b)1Rhr/0
Pcp4tm1.1Kzy/Pcp4+ 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:6113678


Genotype
MGI:6113654
hm1
Allelic
Composition		 Pcp4tm1.1Kzy/Pcp4tm1.1Kzy
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcp4tm1.1Kzy mutation (0 available); any Pcp4 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal lateral ventricle morphology ( J:241597 )
• lateral ventricles of the brain are smaller in volume




Genotype
MGI:6113678
cx2
Allelic
Composition		 Dp(16Cbr1-Fam3b)1Rhr/0
Pcp4tm1.1Kzy/Pcp4+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Cbr1-Fam3b)1Rhr mutation (1 available); any Dp(16Cbr1-Fam3b)1Rhr mutation (1 available)
Pcp4tm1.1Kzy mutation (0 available); any Pcp4 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal brain ependyma motile cilium physiology ( J:241597 )
• mice show rescue of the decreased cilia beating frequency and cilia beating angle seen in Dp(16Cbr1-Fam32b)1Rhr/0 mice to a level slightly, yet significantly, higher than in wild-type mice

nervous system
abnormal brain ependyma motile cilium physiology ( J:241597 )
• mice show rescue of the decreased cilia beating frequency and cilia beating angle seen in Dp(16Cbr1-Fam32b)1Rhr/0 mice to a level slightly, yet significantly, higher than in wild-type mice
increased brain size ( J:241597 )
• rescue of whole brain enlargement is not seen
• lateral ventricles and the dorsal third ventricle are smaller than in Dp(16Cbr1-Fam32b)1Rhr mice and similar in size to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory