Phenotypes associated with this allele

• Allele Symbol: Slc1a5^tm1Tac
• Allele Name: targeted mutation 1, Taconic
• Allele ID: MGI:6113803
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc1a5^tm1Tac/Slc1a5^tm1Tac	involves: 129S/SvEv * C57BL/6	MGI:6113815

Genotype
MGI:6113815

hm1

• Allelic Composition: Slc1a5^tm1Tac/Slc1a5^tm1Tac
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:254980 )

N • CD8+ and regulatory T cell numbers are normal

N • young mice exhibit normal T cell homeostasis

abnormal T-helper 1 cell differentiation ( J:254980 )

• impaired differentiation from naive CD4+ T cell and in vivo in a T cell adoptive transfer model of colitis

• however, TH1 cell proliferation and survival is normal

abnormal T-helper 2 cell differentiation ( J:254980 )

• enhanced

abnormal T-helper 17 cell differentiation ( J:254980 )

• impaired differentiation from naive CD4+ T cell and in vivo in a T cell adoptive transfer model of colitis

• however, TH17 cell proliferation and survival is normal and high concentration of leucine rescues differentiation

decreased B cell number ( J:254980 )

• in the spleen

decreased CD4-positive, alpha-beta memory T cell number ( J:254980 )

• in older mice (5-6 months)

decreased T helper 1 cell number ( J:254980 )

decreased T-helper 17 cell number ( J:254980 )

increased CD4-positive, alpha-beta T cell number ( J:254980 )

• CD44^loCD62L^hi naive CD4+ T cells

abnormal T cell physiology ( J:254980 )

• anti-CD3- and anti-CD28-stimulated T cells exhibit reduced glutamine and leucine uptake but reduced lactate secretion consistent with reduced glycolysis and a failure to produce an initial burst of oxygen consumption compared with wild-type cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:254980 )

• MOG-treated mice exhibit milder clinical scores with reduced inflammation, demyelination and numbers of Th1 and Th17 cells compared with wild-type mice

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:254980 )

• impaired differentiation from naive CD4+ T cell and in vivo in a T cell adoptive transfer model of colitis

• however, TH1 cell proliferation and survival is normal

abnormal T-helper 2 cell differentiation ( J:254980 )

• enhanced

abnormal T-helper 17 cell differentiation ( J:254980 )

• impaired differentiation from naive CD4+ T cell and in vivo in a T cell adoptive transfer model of colitis

• however, TH17 cell proliferation and survival is normal and high concentration of leucine rescues differentiation

decreased B cell number ( J:254980 )

• in the spleen

decreased CD4-positive, alpha-beta memory T cell number ( J:254980 )

• in older mice (5-6 months)

decreased T helper 1 cell number ( J:254980 )

decreased T-helper 17 cell number ( J:254980 )

increased CD4-positive, alpha-beta T cell number ( J:254980 )

• CD44^loCD62L^hi naive CD4+ T cells

abnormal T cell physiology ( J:254980 )

• anti-CD3- and anti-CD28-stimulated T cells exhibit reduced glutamine and leucine uptake but reduced lactate secretion consistent with reduced glycolysis and a failure to produce an initial burst of oxygen consumption compared with wild-type cells