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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gatmem1Btlr
endonuclease-mediated mutation 1, Bruce Beutler
MGI:6113823
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gatmem1Btlr/Gatmem1Btlr C57BL/6J-Gatmem1Btlr MGI:6113841
ht2
 		Gatmem1Btlr/Gatmm1Btlr C57BL/6J-Gatmem1Btlr/Gatmm1Btlr MGI:6113843


Genotype
MGI:6113841
hm1
Allelic
Composition		 Gatmem1Btlr/Gatmem1Btlr
Genetic
Background		 C57BL/6J-Gatmem1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gatmem1Btlr mutation (0 available); any Gatm mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased enterocyte apoptosis ( J:252049 )
• in the colon of DSS-treated mice
abnormal enterocyte proliferation ( J:252049 )
• decreased in the colon of DSS-treated mice
decreased colon length ( J:252049 )
• in DSS-treated mice
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice exhibit decreased creatine levels in intestinal epithelium, excessive cell death in the colon, decreased cell proliferation in the colon and increased colon shortening compared with wild-type mice

homeostasis/metabolism
decreased creatine level ( J:252049 )
• in the intestinal epithelium of DSS-treated mice
increased physiological sensitivity to xenobiotic ( J:252049 )
• mice rectally treated with trinitrobenzenesulfonic acid exhibit increased colonic shortening compared with wild-type mice

cellular
increased enterocyte apoptosis ( J:252049 )
• in the colon of DSS-treated mice
abnormal enterocyte proliferation ( J:252049 )
• decreased in the colon of DSS-treated mice

immune system
immune system phenotype ( J:252049 )
N
• mice exhibit normal peripheral immune responses
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice exhibit decreased creatine levels in intestinal epithelium, excessive cell death in the colon, decreased cell proliferation in the colon and increased colon shortening compared with wild-type mice




Genotype
MGI:6113843
ht2
Allelic
Composition		 Gatmem1Btlr/Gatmm1Btlr
Genetic
Background		 C57BL/6J-Gatmem1Btlr/Gatmm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gatmem1Btlr mutation (0 available); any Gatm mutation (22 available)
Gatmm1Btlr mutation (0 available); any Gatm mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
diarrhea ( J:252049 )
• increased in DSS-treated mice
decreased colon length ( J:252049 )
• in DSS-treated mice
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice exhibit increased weight loss, diarrhea, rectal bleeding and colonic shortening compared with wild-type mice

growth/size/body
increased susceptibility to weight loss ( J:252049 )
• in DSS-treated mice

immune system
increased susceptibility to induced colitis ( J:252049 )
• DSS-treated mice exhibit increased weight loss, diarrhea, rectal bleeding and colonic shortening compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory