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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab11fip1tm1.1Jicn
targeted mutation 1.1, Jim C Norman
MGI:6113874
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Rab11fip1tm1.1Jicn/Rab11fip1tm1.1Jicn
Tg(Pdx1-cre)6Tuv/0
Trp53tm2.1Tyj/Trp53+ 		involves: 129S4/SvJae * FVB/N MGI:6113915


Genotype
MGI:6113915
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Rab11fip1tm1.1Jicn/Rab11fip1tm1.1Jicn
Tg(Pdx1-cre)6Tuv/0
Trp53tm2.1Tyj/Trp53+
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Rab11fip1tm1.1Jicn mutation (0 available); any Rab11fip1 mutation (41 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2.1Tyj mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:244261 )
N
• phenotypes are relative to the control KPC (KrasG12D/+, p53R172H/+, Pdx1-Cre) PDAC (pancreatic adenocarcinoma) model mice
• size of PDAC primary tumors same as control
decreased metastatic potential ( J:244261 )
• significantly reduced number of detectable PDAC metastases to liver, lung and other tissues
• reduced migration of PDAC cells in vitro

mortality/aging
mortality/aging ( J:244261 )
N
• survival same as control




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory