Phenotypes associated with this allele

• Allele Symbol: Cdkn2a^em2Cjs
• Allele Name: endonuclease-mediated mutation 2, Charles J Sherr
• Allele ID: MGI:6113939
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn2a^em2Cjs/Cdkn2a^em2Cjs	C57BL/6-Cdkn2a^em2Cjs	MGI:6114772

Genotype
MGI:6114772

hm1

• Allelic Composition: Cdkn2a^em2Cjs/Cdkn2a^em2Cjs
• Genetic Background: C57BL/6-Cdkn2a^em2Cjs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oligozoospermia ( J:244260 )

♂ • with increasing age

abnormal spermatocyte morphology ( J:244260 )

♂ • p53-dependent apoptosis during pachytene

reproductive system

oligozoospermia ( J:244260 )

♂ • with increasing age

abnormal spermatocyte morphology ( J:244260 )

♂ • p53-dependent apoptosis during pachytene

vision/eye

persistent hyperplastic primary vitreous ( J:244260 )

• caused by abnormal proliferation of mural mesenchymal cells around hyaloid capillary vascular endothelium

retina detachment ( J:244260 )

• caused by aberrant accumulation of mural pericytes and development of a retrolental mass in early postnatal period

binocular blindness ( J:244260 )

• retina detaches and collapses into lens in early postnatal period

neoplasm

neoplasm ( J:244260 )

N • no acute lymphoblastic leukemia (ALL) tumors during 60 days when p185^BCR-ABL positive pro/pre-B cells from cultured bone marrow progenitors from mice with this genotype were injected into wild-type mice