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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dock2m7Btlr
mutation 7, Bruce Beutler
MGI:6114020
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dock2m7Btlr/Dock2m7Btlr C57BL/6J-Dock2m7Btlr MGI:6114022
ht2
 		Dock2m7Btlr/Dock2+ C57BL/6J-Dock2m7Btlr MGI:6114023


Genotype
MGI:6114022
hm1
Allelic
Composition		 Dock2m7Btlr/Dock2m7Btlr
Genetic
Background		 C57BL/6J-Dock2m7Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m7Btlr mutation (0 available); any Dock2 mutation (143 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased neutrophil cell number ( J:255181 )
• in the peripheral blood
decreased B cell number ( J:255181 )
• total B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood
increased NK cell number ( J:255181 )
• in the peripheral blood
increased macrophage cell number ( J:255181 )
• in the peripheral blood

hematopoietic system
increased neutrophil cell number ( J:255181 )
• in the peripheral blood
decreased B cell number ( J:255181 )
• total B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood
increased NK cell number ( J:255181 )
• in the peripheral blood
increased macrophage cell number ( J:255181 )
• in the peripheral blood




Genotype
MGI:6114023
ht2
Allelic
Composition		 Dock2m7Btlr/Dock2+
Genetic
Background		 C57BL/6J-Dock2m7Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m7Btlr mutation (0 available); any Dock2 mutation (143 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased neutrophil cell number ( J:255181 )
• in the peripheral blood
decreased B cell number ( J:255181 )
• total B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood
increased macrophage cell number ( J:255181 )
• in the peripheral blood

hematopoietic system
increased neutrophil cell number ( J:255181 )
• in the peripheral blood
decreased B cell number ( J:255181 )
• total B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood
increased macrophage cell number ( J:255181 )
• in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory