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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl3m1Btlr
mutation 1, Bruce Beutler
MGI:6114031
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl3m1Btlr/Bcl3m1Btlr C57BL/6J-Bcl3m1Btlr MGI:6114033
ht2
 		Bcl3m1Btlr/Bcl3+ C57BL/6J-Bcl3m1Btlr MGI:6114034


Genotype
MGI:6114033
hm1
Allelic
Composition		 Bcl3m1Btlr/Bcl3m1Btlr
Genetic
Background		 C57BL/6J-Bcl3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl3m1Btlr mutation (0 available); any Bcl3 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B-1 B cell number ( J:255184 )
• in the peripheral blood
decreased B cell number ( J:255184 )
• in the peripheral blood
decreased B-1b cell number ( J:255184 )
• in the peripheral blood
increased macrophage cell number ( J:255184 )
• in the peripheral blood
abnormal humoral immune response ( J:255184 )
• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgG level ( J:255184 )
• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system
increased B-1 B cell number ( J:255184 )
• in the peripheral blood
decreased B cell number ( J:255184 )
• in the peripheral blood
decreased B-1b cell number ( J:255184 )
• in the peripheral blood
increased macrophage cell number ( J:255184 )
• in the peripheral blood
decreased IgG level ( J:255184 )
• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)




Genotype
MGI:6114034
ht2
Allelic
Composition		 Bcl3m1Btlr/Bcl3+
Genetic
Background		 C57BL/6J-Bcl3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl3m1Btlr mutation (0 available); any Bcl3 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:255184 )
• in the peripheral blood
decreased B-1b cell number ( J:255184 )
• in the peripheral blood
increased macrophage cell number ( J:255184 )
• in the peripheral blood

hematopoietic system
decreased B cell number ( J:255184 )
• in the peripheral blood
decreased B-1b cell number ( J:255184 )
• in the peripheral blood
increased macrophage cell number ( J:255184 )
• in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory