Phenotypes associated with this allele

• Allele Symbol: Cdkn2a^em1Cjs
• Allele Name: endonuclease-mediated mutation 1, Charles J Sherr
• Allele ID: MGI:6114043
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn2a^em1Cjs/Cdkn2a^em1Cjs	B6.Cg-Cdkn2a^em1Cjs	MGI:6114768

Genotype
MGI:6114768

hm1

• Allelic Composition: Cdkn2a^em1Cjs/Cdkn2a^em1Cjs
• Genetic Background: B6.Cg-Cdkn2a^em1Cjs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased testis weight ( J:244260 )

♂

neoplasm

increased acute lymphoblastic leukemia incidence ( J:244260 )

• when p185^BCR-ABL positive pro/pre-B cells from cultured bone marrow progenitors from mice with this genotype were injected into wild-type mice

reproductive system

reproductive system phenotype ( J:244260 )

♂N • fertility and sperm count

increased testis weight ( J:244260 )

♂

vision/eye

vision/eye phenotype ( J:244260 )

N • no blindness, retinal detachment or persistent capillary vasculature in vitreous