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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PrkdcM11Btlr
mutation 11, Bruce Beutler
MGI:6114652
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PrkdcM11Btlr/PrkdcM11Btlr C57BL/6J-PrkdcM11Btlr MGI:6114654
ht2
 		PrkdcM11Btlr/Prkdc+ C57BL/6J-PrkdcM11Btlr MGI:6114655


Genotype
MGI:6114654
hm1
Allelic
Composition		 PrkdcM11Btlr/PrkdcM11Btlr
Genetic
Background		 C57BL/6J-PrkdcM11Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM11Btlr mutation (0 available); any Prkdc mutation (418 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgM level ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
enhanced humoral immune response ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
increased IgM level ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:6114655
ht2
Allelic
Composition		 PrkdcM11Btlr/Prkdc+
Genetic
Background		 C57BL/6J-PrkdcM11Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkdcM11Btlr mutation (0 available); any Prkdc mutation (418 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgM level ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
enhanced humoral immune response ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
increased IgM level ( J:255270 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory