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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pi16tm1.2Engl
targeted mutation 1.2, Stefan Engelhardt
MGI:6114785
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pi16tm1.2Engl/Pi16tm1.2Engl involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * SJL MGI:6115035


Genotype
MGI:6115035
hm1
Allelic
Composition
Pi16tm1.2Engl/Pi16tm1.2Engl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pi16tm1.2Engl mutation (0 available); any Pi16 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• heart weight to body weight ratio (no hypertrophy) and extent of extracellular matrix (no fibrosis) at 8 months old

homeostasis/metabolism
N
• basal blood parameters recorded 1, 3, 5 and 8 months postnatal: WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, MPV
• fails to inhibit proteolytic activation of chemokine pro-chemerin (Rarres2)

immune system
• fails to inhibit proteolytic activation of chemokine pro-chemerin (Rarres2)

reproductive system
N
• litter size and gender balance





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory