Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-cat,-ALOX15)1868Klv
• Allele Name: transgene insertion 1868, Uddhav P Kelavkar
• Allele ID: MGI:6114990
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-cat,-ALOX15)1868Klv/0 Tg(Pbsn-cre)4Prb/0	involves: C57BL/6 * DBA/2	MGI:6114993
cn2	Tg(CAG-cat,-ALOX15)1868Klv/Tg(CAG-cat,-ALOX15)1868Klv Tg(Pbsn-cre)4Prb/?	involves: C57BL/6 * DBA/2	MGI:6114995

Genotype
MGI:6114993

cn1

• Allelic Composition: Tg(CAG-cat,-ALOX15)1868Klv/0; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:114903 )

♂ • dorsolateral and ventral prostates show age-dependent focal and progressive epithelial hyperplasia with atypia which shows increased proliferation indicating high grade prostatic intraepithelial neoplasia after 5 months of age

♂ • micropapillary projections of mildly atypical epithelium are seen in distal dorsal prostate lumens and nuclei show mild enlargement, including elongation and hyperchromasia

♂ • lateral prostate shows progressively severe nuclear stratification, with nuclear atypia with some enlargement and hyperchromasia with chromatin clumping

♂ • however, no progression to invasive prostate cancer was seen up to 35 weeks

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:114903 )

♂ • dorsolateral and ventral prostates show age-dependent focal and progressive epithelial hyperplasia with atypia which shows increased proliferation indicating high grade prostatic intraepithelial neoplasia after 5 months of age

♂ • micropapillary projections of mildly atypical epithelium are seen in distal dorsal prostate lumens and nuclei show mild enlargement, including elongation and hyperchromasia

♂ • lateral prostate shows progressively severe nuclear stratification, with nuclear atypia with some enlargement and hyperchromasia with chromatin clumping

♂ • however, no progression to invasive prostate cancer was seen up to 35 weeks

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:114903 )

♂ • dorsolateral and ventral prostates show age-dependent focal and progressive epithelial hyperplasia with atypia which shows increased proliferation indicating high grade prostatic intraepithelial neoplasia after 5 months of age

♂ • micropapillary projections of mildly atypical epithelium are seen in distal dorsal prostate lumens and nuclei show mild enlargement, including elongation and hyperchromasia

♂ • lateral prostate shows progressively severe nuclear stratification, with nuclear atypia with some enlargement and hyperchromasia with chromatin clumping

♂ • however, no progression to invasive prostate cancer was seen up to 35 weeks

Genotype
MGI:6114995

cn2

• Allelic Composition: Tg(CAG-cat,-ALOX15)1868Klv/Tg(CAG-cat,-ALOX15)1868Klv; Tg(Pbsn-cre)4Prb/?
• Genetic Background: involves: C57BL/6 * DBA/2

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:114903 )

♂ • dorsolateral and ventral prostates show age-dependent focal and progressive epithelial hyperplasia with atypia which shows increased proliferation indicating high grade prostatic intraepithelial neoplasia after 5 months of age

♂ • micropapillary projections of mildly atypical epithelium are seen in distal dorsal prostate lumens and nuclei show mild enlargement, including elongation and hyperchromasia

♂ • lateral prostate shows progressively severe nuclear stratification, with nuclear atypia with some enlargement and hyperchromasia with chromatin clumping

♂ • however, no progression to invasive prostate cancer was seen up to 35 weeks

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:114903 )

♂ • dorsolateral and ventral prostates show age-dependent focal and progressive epithelial hyperplasia with atypia which shows increased proliferation indicating high grade prostatic intraepithelial neoplasia after 5 months of age

♂ • micropapillary projections of mildly atypical epithelium are seen in distal dorsal prostate lumens and nuclei show mild enlargement, including elongation and hyperchromasia

♂ • lateral prostate shows progressively severe nuclear stratification, with nuclear atypia with some enlargement and hyperchromasia with chromatin clumping

♂ • however, no progression to invasive prostate cancer was seen up to 35 weeks

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:114903 )

♂ • dorsolateral and ventral prostates show age-dependent focal and progressive epithelial hyperplasia with atypia which shows increased proliferation indicating high grade prostatic intraepithelial neoplasia after 5 months of age

♂ • micropapillary projections of mildly atypical epithelium are seen in distal dorsal prostate lumens and nuclei show mild enlargement, including elongation and hyperchromasia

♂ • lateral prostate shows progressively severe nuclear stratification, with nuclear atypia with some enlargement and hyperchromasia with chromatin clumping

♂ • however, no progression to invasive prostate cancer was seen up to 35 weeks