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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sec22btm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6115369
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sec22btm1c(EUCOMM)Wtsi/Sec22btm1c(EUCOMM)Wtsi
Tg(Itgax-cre)1-1Reiz/0 		involves: C57BL/6 * C57BL/6N * CBA * SJL MGI:6156916


Genotype
MGI:6156916
cn1
Allelic
Composition		 Sec22btm1c(EUCOMM)Wtsi/Sec22btm1c(EUCOMM)Wtsi
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec22btm1c(EUCOMM)Wtsi mutation (0 available); any Sec22b mutation (15 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:255769 )
N
• development of dendritic cell (DC), myeloid cell, T cell and other lymphoid populations, and thymocyte differentiation and T cell activation state
• dendritic cell (DC) development, cytokine response to toll-like receptor (Tlr) stimulation, direct antigen presentation, and endocytic antigen uptake
• in vivo cross-presentation of soluble antigens
• in vitro cross-presentation of soluble or particulate antigens using splenic Cd11c+ DCs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory