Phenotypes associated with this allele

• Allele Symbol: Slc17a9^tm1Nomu
• Allele Name: targeted mutation 1, Masatoshi Nomura
• Allele ID: MGI:6116235
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc17a9^tm1Nomu/Slc17a9^tm1Nomu	involves: 129 * C57BL/6J	MGI:6116280

Genotype
MGI:6116280

hm1

• Allelic Composition: Slc17a9^tm1Nomu/Slc17a9^tm1Nomu
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:256580 )

N • serum glucagon and adrenaline levels

N • no obvious phenotype regarding weight gain, food intake, water intake, oxygen consumption, carbon dioxide emission or respiratory exchange ratio (RER)

hypoglycemia ( J:256580 )

• significantly lower fasting blood glucose level

decreased circulating insulin level ( J:256580 )

• after oral or intraperitoneal injection of glucose

abnormal catecholamine level ( J:256580 )

• reduced catecholamine content in adrenal chromaffin cells

improved glucose tolerance ( J:256580 )

• after oral or intraperitoneal injection of glucose

increased insulin sensitivity ( J:256580 )

• according to insulin tolerance test

endocrine/exocrine glands

abnormal adrenal gland physiology ( J:256580 )

• absent vesicular ATP transport in adrenal chromaffin cells

• reduced catecholamine content in adrenal chromaffin cells

abnormal neuroendocrine gland physiology ( J:256580 )

• reduced catecholamine content in adrenal chromaffin cells

• absent vesicular ATP transport in adrenal chromaffin cells

nervous system

abnormal neuroendocrine gland physiology ( J:256580 )

• reduced catecholamine content in adrenal chromaffin cells

• absent vesicular ATP transport in adrenal chromaffin cells

behavior/neurological

behavior/neurological phenotype ( J:256580 )

N • no obvious phenotype regarding locomotor activity, and open field and plus maze behaviors

growth/size/body

growth/size/body region phenotype ( J:256580 )

N • no obvious phenotype regarding weight gain, body size, morphology, food intake or water intake

respiratory system

respiratory system phenotype ( J:256580 )

N • no obvious phenotype regarding oxygen consumption, carbon dioxide emission or respiratory exchange ratio (RER)