Analysis Tools
growth/size/body
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• on a standard chow diet, both male and female homozygotes exhibit reduced body weight at 24, 28 and 32 weeks of age relative to age-matched wild-type controls
• however, daily food intake and fecal excretion is normal and no differences in white and brown adipose tissue weight or organ weight are observed
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• starting at 24 weeks of age, both male and female homozygotes gain less weight on average than wild-type controls
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digestive/alimentary system
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• at 8 weeks of age, the frequency of peristaltic contraction in the jejunum is higher than that in wild-type controls when the resting intraluminal pressure is 3 cmH2O
• at 32 weeks of age, the frequency of peristalsis in the jejunum is higher than that in wild-type controls at resting intraluminal pressures of 2 or 3 cmH2O
• at 32 weeks of age, the frequency of slow wave potential in the jejunum is higher than that in wild-type controls at resting intraluminal pressures of 1, 2 and 3 cmH2O
• however, the amplitudes of peristalsis at resting intraluminal pressures of 0, 1, 2 and 3 cmH2O are normal
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muscle
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• at 8 weeks of age, the frequency of peristaltic contraction in the jejunum is higher than that in wild-type controls when the resting intraluminal pressure is 3 cmH2O
• at 32 weeks of age, the frequency of peristalsis in the jejunum is higher than that in wild-type controls at resting intraluminal pressures of 2 or 3 cmH2O
• at 32 weeks of age, the frequency of slow wave potential in the jejunum is higher than that in wild-type controls at resting intraluminal pressures of 1, 2 and 3 cmH2O
• however, the amplitudes of peristalsis at resting intraluminal pressures of 0, 1, 2 and 3 cmH2O are normal
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