All Phenotypes Frs3<tm1Jheb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Frs3^tm1Jheb
targeted mutation 1, Jean M Hebert
MGI:6116679

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Frs3^tm1Jheb/Frs3^tm1Jheb	involves: 129 * Swiss Webster	MGI:6116889
cn2	Fgfr2^tm1Dor/Fgfr2^tm1Dor Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Frs3^tm1Jheb/Frs3^tm1Jheb	involves: 129	MGI:6116891
cn3	Fgfr2^tm1Dor/Fgfr2⁺ Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Frs3^tm1Jheb/Frs3^tm1Jheb	involves: 129	MGI:6116892
cn4	Fgfr2^tm1Dor/Fgfr2^tm1Dor Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm3.1Sor/Fgfr1^tm1Jpa Frs3^tm1Jheb/Frs3^tm1Jheb	involves: 129	MGI:6116893
cn5	Foxg1^tm1(cre)Skm/Foxg1⁺ Frs2^tm1Fwan/Frs2^tm1Fwan Frs3^tm1Jheb/Frs3^tm1Jheb	involves: 129 * Swiss Webster	MGI:6116890

Allelic Composition	Frs3^tm1Jheb/Frs3^tm1Jheb
Genetic Background	involves: 129 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frs3^tm1Jheb mutation (0 available); any Frs3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:242687 )

N	• adult mice show normal appearance

reproductive system

reproductive system phenotype ( J:242687 )

• fertile

Allelic Composition	Fgfr2^tm1Dor/Fgfr2^tm1Dor Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Frs3^tm1Jheb/Frs3^tm1Jheb
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Fgfr3^tm6.1Cxd mutation (0 available); any Fgfr3 mutation (54 available)
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Frs3^tm1Jheb mutation (0 available); any Frs3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent telencephalon ( J:242687 )

• at E12.5

Allelic Composition	Fgfr2^tm1Dor/Fgfr2⁺ Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Frs3^tm1Jheb/Frs3^tm1Jheb
Genetic Background	involves: 129

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:242687 )

N	• cell survival and cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity

nervous system

nervous system phenotype ( J:242687 )

N	• brain morphology at E12.5

Allelic Composition	Fgfr2^tm1Dor/Fgfr2^tm1Dor Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm3.1Sor/Fgfr1^tm1Jpa Frs3^tm1Jheb/Frs3^tm1Jheb
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1^tm3.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Fgfr3^tm6.1Cxd mutation (0 available); any Fgfr3 mutation (54 available)
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Frs3^tm1Jheb mutation (0 available); any Frs3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:242687 )

N	• cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity

increased cell death ( J:242687 )

• according to TUNEL assay at E8.75

nervous system

absent telencephalon ( J:242687 )

• at E12.5

Allelic Composition	Foxg1^tm1(cre)Skm/Foxg1⁺ Frs2^tm1Fwan/Frs2^tm1Fwan Frs3^tm1Jheb/Frs3^tm1Jheb
Genetic Background	involves: 129 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Frs2^tm1Fwan mutation (0 available); any Frs2 mutation (63 available)
Frs3^tm1Jheb mutation (0 available); any Frs3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:242687 )

N	• differentiating field of cortical GABAergic interneurons at E13.5 according to Shh and Lhx6 labeling

abnormal cortical ventricular zone morphology ( J:242687 )

• reduced size of Dlx2-labeled region at E13.5

telencephalon hypoplasia ( J:242687 )

• reduction in size across A/P (-24%) and D/V (-16%) axes at E13.5

abnormal embryonic/fetal subventricular zone morphology ( J:242687 )

• reduced cell division at E13.5 according to mitotic marker p-HH3 immunoreactivity

abnormal lateral ganglionic eminence morphology ( J:242687 )

• reduction in subset of dopaminergic olfactory interneuron progenitors in dorsal LGE at E13.5 according to Pax6 labeling

abnormal medial ganglionic eminence morphology ( J:242687 )

• reduced size of Nkx2-1-labeled region in MGE and pre-optic area at E13.5

• size of Nkx2-1-labeled region in MGE and pre-optic area at E10.5

• reduced size of Lhx8-labeled differentiating domain at E13.5

craniofacial

frontonasal prominence hypoplasia ( J:242687 )

• at E10.5 and E13.5

vision/eye

microphthalmia ( J:242687 )

• at E13.5

cellular

cellular phenotype ( J:242687 )

N	• cell survival in telencephalon at E10.5 and E13.5

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