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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc62em1Jxia
endonuclease-mediated mutation 1, Jun Xia
MGI:6116688
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc62em1Jxia/Ccdc62em1Jxia C57BL/6-Ccdc62em1Jxia MGI:6116697
ht2
 		Ccdc62em1Jxia/Ccdc62+ C57BL/6-Ccdc62em1Jxia MGI:6116698


Genotype
MGI:6116697
hm1
Allelic
Composition		 Ccdc62em1Jxia/Ccdc62em1Jxia
Genetic
Background		 C57BL/6-Ccdc62em1Jxia
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc62em1Jxia mutation (0 available); any Ccdc62 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:244081 )
N
• fertile
• litter size
teratozoospermia ( J:244081 )
• most sperm malformed
abnormal sperm midpiece morphology ( J:244081 )
• enclosed within a cytoplasm bag
• wrapped around sperm head
abnormal sperm head morphology ( J:244081 )
• flagellum midpiece wrapped around head
• enclosed within a cytoplasm bag
asthenozoospermia ( J:244081 )
• motility of cauda epididymal sperm reduced to less than 10% of wild-type
male infertility ( J:244081 )
• after 2 months mating with wild-type or heterozygous KO females
• normal sperm count

cellular
teratozoospermia ( J:244081 )
• most sperm malformed
abnormal sperm midpiece morphology ( J:244081 )
• enclosed within a cytoplasm bag
• wrapped around sperm head
abnormal sperm head morphology ( J:244081 )
• flagellum midpiece wrapped around head
• enclosed within a cytoplasm bag
asthenozoospermia ( J:244081 )
• motility of cauda epididymal sperm reduced to less than 10% of wild-type




Genotype
MGI:6116698
ht2
Allelic
Composition		 Ccdc62em1Jxia/Ccdc62+
Genetic
Background		 C57BL/6-Ccdc62em1Jxia
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc62em1Jxia mutation (0 available); any Ccdc62 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:244081 )
N
• males are fertile, generating a normal litter size when mated with heterozygous KO females; sperm count is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory